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• W4236177712 abstract "Age-related white matter injury is associated with a white matter hyperintensity (WMH) penumbra, or “at risk” tissue. Previous research by our laboratory has identified a WMH CBF penumbra extending approximately 12 mm from both periventricular (PVWMH) and deep WMHs (DWMH) using magnetic resonance imaging (MRI) pulsed arterial spin labeling (PASL). Longitudinal data demonstrated WMH expansion occurring approximately 5 mm surrounding WMH lesions. The aim of our current study is to examine the longitudinal characteristics of diffusion tensor imaging fractional anisotropy (DTI-FA) and fluid-attenuated inversion recovery (FLAIR) intensity within the WMH CBF penumbra. Twenty-four cognitively intact elderly volunteers (mean age=84.3, CDR=0, MMSE=28.9) underwent 2 visits of 3T MRI FLAIR, MPRAGE, PASL and DTI. The mean interscan interval was 18 months. For each individual dataset, baseline and follow-up WMH on FLAIR images were defined and then linearly aligned. The voxels with new PVWMHs at follow-up, we refer to as new WMH voxels, and voxels which maintained NAWM in follow-up, we refer to as persistent normal-appearing white matter (NAWM) voxels. We used baseline WMHs as seeds to create the complement NAWM layer mask. Each layer was dilated away from the WMHs by 1 mm. The NAWM mask was applied to the baseline and follow-up CBF, DTI-FA and FLAIR images, which were previously linearly coregistered to the baseline MPRAGE. Lastly, we calculated the mean baseline and follow-up CBF, DTI-FA, and FLAIR intensity of new WMH and persistent NAWM voxels of each layer. The entire process was performed for PVWMH and DWMH separately. Mean baseline CBF was significantly lower (p≤0.001), FLAIR intensity was significantly higher (p≤0.001), and FA was significantly lower (p≤0.001) for new WMH voxels compared with persistent NAWM voxels. Higher FLAIR and lower FA precedes the development of new WMH voxels, suggesting that FLAIR intensity and DTI-FA within the previously defined WMH CBF penumbra are associated with WMH expansion over time, and can be used as an imaging marker of WM health or vulnerability in “at risk” tissue. We found this for both PVWMH and DWMH, implying the results were not affected by anatomical variance in WM integrity. The group mean (plusminus symbol)baseline CBF (A and B), Flair intensity (C and D), and FA (E and F) of NAWM layers 1,2,3,4,5, and mean of all 5 layers of new WMH voxels in relation to voxels that persisted as NAWM at follow-up NAWM layer 1 (L1) is the closest layer to the baseline WMH. The left and right columns represent the data for the PVWMH and DWMH respectively. Asterisk indicates there is a significant difference between the baseline CBF, FLAIR intensity, and FA for the two voxel groups, p < 0.05." @default.
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• W4236177712 date "2015-07-01" @default.
• W4236177712 modified "2023-10-16" @default.
• W4236177712 title "IC-P-150: Characteristics of DTI-FA and flair intensity within white matter hyperintensity cerebral blood flow penumbra: A longitudinal study" @default.
• W4236177712 doi "https://doi.org/10.1016/j.jalz.2015.06.172" @default.
• W4236177712 hasPublicationYear "2015" @default.
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