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- W4236204551 abstract "During the past five years, the development of tau-specific PET tracers has enabled the visualization of tau deposits in Alzheimer's disease (AD) as well as other tauopathies. In vitro evidence highlights differences in the binding characteristics of tau-specific PET tracers, deriving from different chemical families. In this study we evaluated in vivo and in the same patients with AD the binding of two chemically different tau-specific PET tracers, [11C]THK5351 and [11C]PBB3. Ten patients with prodromal AD or AD dementia (63.9±6.2yrs.) were recruited after thorough clinical assessment. More specifically, all patients had objective cognitive impairment (MMSE=27.6±2.1) and CSF biomarker evidence supportive of the presence of AD pathological changes (Dubois, B. et al. Lancet Neurol. 2014). All patients underwent multimodal imaging with the tau-specific tracers [11C]THK5351 and [11C]PBB3 on the same day, the amyloid-specific tracer [11C]AZD2184 as well as a T1 MRI sequence. All patients showed high widespread cortical binding of the amyloid-specific tracer [11C]AZD2184. Binding of the tau-specific tracers, [11C]THK5351 and [11C]PBB3, was observed in the temporal lobes as well as other isocortical areas, however, the distribution pattern was distinct from that of [11C]AZD2184 binding. Greater load of grey matter binding was observed for [11C]THK5351 in comparison to [11C]PBB3, with regional differences noted in the binding patterns of the tau tracers, especially in the temporal lobes. Distinct areas showing off-target binding for every tracer were identified. The tau-specific tracers, [11C]THK5351 and [11C]PBB3, show differences in both the load and the regional distribution of their binding in the brains of patients with AD. This research provides insight into the interaction of two chemically different tau tracers with tau aggregates and sheds new light in the relationship between tau tracers’ binding with other markers of the disease." @default.
- W4236204551 created "2022-05-12" @default.
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- W4236204551 date "2017-07-01" @default.
- W4236204551 modified "2023-10-03" @default.
- W4236204551 title "[P2-366]: HEAD-TO-HEAD IN VIVO COMPARISON OF TAU-SPECIFIC PET TRACERS IN ALZHEIMER's DISEASE: [11 C]THK5351 VERSUS [11 C]PBB3 PET IMAGING" @default.
- W4236204551 doi "https://doi.org/10.1016/j.jalz.2017.06.1021" @default.
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