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- W4236225746 abstract "PURPOSE Recent research suggests that persons with a predominance of small LDL particles (LDL pattern B) may respond differently to short-term therapeutic lifestyle changes (TLC) as compared to persons with a predominance of large LDL particles (LDL pattern A). However, scarce long-term data are available to substantiate or refute this possibility. In this study, we compared the effect of 1 year of TLC on plasma lipids and lipoproteins in participants with LDL pattern B (n=11; LDL size <20.6 nm) versus LDL pattern A (n=50; LDL size>20.5 nm), as determined using NMR spectroscopy. METHODS TLC included counseling on a low fat (20% of daily calories)/high complex carbohydrate (60% of daily calories) diet and exercise training. Counseling was provided by healthcare professionals via telephone and the Internet. Participants were evaluated at baseline and after 1 year using standardized procedures. No changes in antilipemic medications occurred between evaluations. RESULTS Body weight decreased to a similar degree in participants with LDL pattern B (−5.4 lbs, p<0.05) versus LDL pattern A (−5.2 lbs, p<0.05). In contrast, participants with LDL pattern B tended to derive more favorable changes in total cholesterol (−15 mg/dl, p<0.05 versus −3 mg/dl, p=NS; p<0.05 for pattern B versus A participants), LDL cholesterol (−11 mg/dl, p<0.05 versus −6 mg/dl, p<0.05; p=NS for pattern B versus A participants), LDL particle number (−291 nmol/L, p<0.05 versus −91 nmol/L, p<0.05; p<0.05 for pattern B versus A participants), LDL particle size (0.5 nm, p<0.05 versus 0.1 nm, p=NS; p<0.05 for pattern B versus A participants), HDL cholesterol (6 mg/dl, p<0.05 versus 3 mg/dl, p<0.05; p=NS for pattern B versus A participants); large HDL cholesterol (4 mg/dl, p<0.05 versus 4 mg/dl, p<0.05; p=NS for pattern B versus A participants), triglycerides (−91 mg/dl, p<0.05 versus −3 mg/dl, p=NS; p<0.05 for pattern B versus A participants), and large VLDL cholesterol (−58 mg/dl, p=NS versus 6 mg/dl, p=NS; p<0.05 for pattern B versus A participants). CONCLUSIONS Although additional research is warranted, these data support the notion that individuals with LDL pattern B may be more responsive to a long-term program of TLC that includes a low fat/high complex carbohydrate diet and exercise training as compared to individuals with LDL pattern A." @default.
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- W4236225746 date "2005-05-01" @default.
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- W4236225746 title "Clinical Effectiveness Of Therapeutic Lifestyle Changes In Patients With Low-density Lipoprotein Subclass Pattern B Versus A" @default.
- W4236225746 doi "https://doi.org/10.1249/00005768-200505001-01976" @default.
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