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- W4236226786 abstract "This chapter focuses on radiation chimeras. The term chimera has been used for many years to indicate organisms housing mixtures of genetically different cells. It was realized that the establishment of chimerism was consequent upon suppression of immune responses by radiation. The various methods by which radiation chimeras have been produced and described have been outlined in the chapter. Irradiation of mice has usually been by a single, unilateral, relatively short exposure at a dose rate between 10 and 200 r per minute. The best way to ensure equal irradiation of a number of mice is to rotate them slowly in the beam in a circular Lucite container. Radiations other than X-rays (and y-rays) have not often been used to deplete the hematopoietic system prior to an implant of foreign tissue. The dose of total-body radiation that proves lethal to mammals is dependent on the period of time over which the radiation is administered. The general practice in work with mouse chimeras has been to use animals about 12 weeks of age as hosts. Various methods have been used to prepare donor cells for injection into irradiated animals. With mice, bone marrow can be obtained from dissected femurs by removing the epiphyses and avulsing the marrow with a hypodermic needle. Any route of injection of donor cells that is consistent with the migration of a sufficient number of blast cells to normal hematopoietic sites is suitable. The different hematopoietic tissues used as donor material contain different proportions of the various stem cell types and it is the number of these cells which probably determines the survival of chimeras." @default.
- W4236226786 created "2022-05-12" @default.
- W4236226786 creator A5043075945 @default.
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- W4236226786 creator A5073526001 @default.
- W4236226786 date "1962-01-01" @default.
- W4236226786 modified "2023-09-28" @default.
- W4236226786 title "Radiation Chimeras" @default.
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