Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236274101> ?p ?o ?g. }
- W4236274101 endingPage "2066" @default.
- W4236274101 startingPage "2057" @default.
- W4236274101 abstract "The beta-globin gene complex is regulated by an upstream locus control region (LCR) which is responsible for high-level, position-independent, erythroid-cell-specific expression of the genes in the cluster. Its role in the developmental regulation of beta-like globin gene transcription remains to be established. We have examined the effect of a single LCR element, hypersensitive site 2 (HS2), on the developmental regulation of the human fetal gamma and adult beta genes in transgenic mice. In mice bearing HS2A gamma beta and HS2G gamma A gamma-117 delta beta human globin gene constructs, switching from gamma- to beta-gene expression begins at about day 13.5 of gestation and is largely completed shortly after birth. The larger construct also demonstrates a switch in G gamma- to A gamma-gene expression during the gamma-to-beta switch similar to that observed during normal human development. We conclude that HS2 alone is sufficient for developmental regulation of the human beta-globin genes." @default.
- W4236274101 created "2022-05-12" @default.
- W4236274101 creator A5003044776 @default.
- W4236274101 creator A5055644792 @default.
- W4236274101 creator A5055931070 @default.
- W4236274101 creator A5058153140 @default.
- W4236274101 creator A5059302506 @default.
- W4236274101 creator A5082544812 @default.
- W4236274101 date "1992-05-01" @default.
- W4236274101 modified "2023-09-26" @default.
- W4236274101 title "A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice" @default.
- W4236274101 cites W1595583901 @default.
- W4236274101 cites W1714683344 @default.
- W4236274101 cites W1821914260 @default.
- W4236274101 cites W1967868770 @default.
- W4236274101 cites W1975990934 @default.
- W4236274101 cites W1978667215 @default.
- W4236274101 cites W1979692126 @default.
- W4236274101 cites W1993532214 @default.
- W4236274101 cites W2000550375 @default.
- W4236274101 cites W2006558753 @default.
- W4236274101 cites W2006918190 @default.
- W4236274101 cites W2009569586 @default.
- W4236274101 cites W2010264165 @default.
- W4236274101 cites W2015980850 @default.
- W4236274101 cites W2022274660 @default.
- W4236274101 cites W2041117540 @default.
- W4236274101 cites W2041798627 @default.
- W4236274101 cites W2046977202 @default.
- W4236274101 cites W2050206304 @default.
- W4236274101 cites W2055643269 @default.
- W4236274101 cites W2077656754 @default.
- W4236274101 cites W2078575583 @default.
- W4236274101 cites W2079149764 @default.
- W4236274101 cites W2084364631 @default.
- W4236274101 cites W2085631191 @default.
- W4236274101 cites W2086432537 @default.
- W4236274101 cites W2091397900 @default.
- W4236274101 cites W2091399084 @default.
- W4236274101 cites W2094339131 @default.
- W4236274101 cites W2096998693 @default.
- W4236274101 cites W2099600190 @default.
- W4236274101 cites W2111885793 @default.
- W4236274101 cites W2118167494 @default.
- W4236274101 cites W2118299921 @default.
- W4236274101 cites W2125365759 @default.
- W4236274101 cites W2133710414 @default.
- W4236274101 cites W2142071465 @default.
- W4236274101 cites W2142877553 @default.
- W4236274101 cites W2169578753 @default.
- W4236274101 cites W4294216491 @default.
- W4236274101 doi "https://doi.org/10.1128/mcb.12.5.2057-2066.1992" @default.
- W4236274101 hasPublicationYear "1992" @default.
- W4236274101 type Work @default.
- W4236274101 citedByCount "3" @default.
- W4236274101 crossrefType "journal-article" @default.
- W4236274101 hasAuthorship W4236274101A5003044776 @default.
- W4236274101 hasAuthorship W4236274101A5055644792 @default.
- W4236274101 hasAuthorship W4236274101A5055931070 @default.
- W4236274101 hasAuthorship W4236274101A5058153140 @default.
- W4236274101 hasAuthorship W4236274101A5059302506 @default.
- W4236274101 hasAuthorship W4236274101A5082544812 @default.
- W4236274101 hasBestOaLocation W42362741012 @default.
- W4236274101 hasConcept C101762097 @default.
- W4236274101 hasConcept C102230213 @default.
- W4236274101 hasConcept C104317684 @default.
- W4236274101 hasConcept C125996951 @default.
- W4236274101 hasConcept C150194340 @default.
- W4236274101 hasConcept C153911025 @default.
- W4236274101 hasConcept C165864922 @default.
- W4236274101 hasConcept C199360897 @default.
- W4236274101 hasConcept C21592294 @default.
- W4236274101 hasConcept C2776174256 @default.
- W4236274101 hasConcept C36857842 @default.
- W4236274101 hasConcept C39981086 @default.
- W4236274101 hasConcept C41008148 @default.
- W4236274101 hasConcept C54355233 @default.
- W4236274101 hasConcept C84597430 @default.
- W4236274101 hasConcept C86803240 @default.
- W4236274101 hasConceptScore W4236274101C101762097 @default.
- W4236274101 hasConceptScore W4236274101C102230213 @default.
- W4236274101 hasConceptScore W4236274101C104317684 @default.
- W4236274101 hasConceptScore W4236274101C125996951 @default.
- W4236274101 hasConceptScore W4236274101C150194340 @default.
- W4236274101 hasConceptScore W4236274101C153911025 @default.
- W4236274101 hasConceptScore W4236274101C165864922 @default.
- W4236274101 hasConceptScore W4236274101C199360897 @default.
- W4236274101 hasConceptScore W4236274101C21592294 @default.
- W4236274101 hasConceptScore W4236274101C2776174256 @default.
- W4236274101 hasConceptScore W4236274101C36857842 @default.
- W4236274101 hasConceptScore W4236274101C39981086 @default.
- W4236274101 hasConceptScore W4236274101C41008148 @default.
- W4236274101 hasConceptScore W4236274101C54355233 @default.
- W4236274101 hasConceptScore W4236274101C84597430 @default.
- W4236274101 hasConceptScore W4236274101C86803240 @default.
- W4236274101 hasIssue "5" @default.
- W4236274101 hasLocation W42362741011 @default.
- W4236274101 hasLocation W42362741012 @default.