Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236304019> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4236304019 abstract "Abstract Background: The purpose of this study was to investigate the risk factors for elevating homocysteine during pregnancy and the relative effects on preeclampsia, so as to further understand whether Hcy had predictive value for PE.Method: This is a prospective study that only covers pregnant women with singleton who received regular prenatal care from July to September 2018 exclusively at IPMCH (N=1142). Homocysteine, folic acid and vitamin B12 were tested in the 1 st trimester (10-14 weeks), 2 nd trimester (24-28 weeks), and 3 rd trimester (30-34 weeks), respectively, and MTHFR genes (rs1801133, rs1801131, rs17367504) were detected. Therefore, the analysis of this case includes the variation in Hcy levels during pregnancy, risk factors for elevating homocysteine and the risk factors on preeclampsia.Results: (1) Homocysteine was lowest in the 1 st trimester. (2) Homocysteine was negatively correlated with folic acid (r=-0.17, p <0.001) and vitamin B12 (r=-0.15, p <0.001) in the same trimester. (3) Both of heterozygous CT ( p =0.025, 95% CI 0.018, 0.275) and homozygous TT ( p <0.001, 95% CI 0.185, 0.501) in MTHFR rs1801133 might be risk factors that caused an increase in Hcy. G-spot mutations in MTHFR rs17367504 might be a risk factor that caused a decline in homocysteine. (4) Homocysteine in the 3 rd trimester might be significantly correlated with increasing risk of preeclampsia (OR = 1.2, 95% CI 1.01,1.42), particularly early-onset preeclampsia (OR = 3.63, 95% CI 1.71,7.71) and severe preeclampsia (OR = 3.63, 95% CI 1.71,7.71).Conclusions: The variation in homocysteine level in the third trimester might be associated with preeclampsia, especially early-onset preeclampsia and severe preeclampsia, and MTHFR, folic acid and vitamin B12 might be the three critical factors responsible for the changing homocysteine levels during pregnancy." @default.
- W4236304019 created "2022-05-12" @default.
- W4236304019 creator A5001027254 @default.
- W4236304019 creator A5031565242 @default.
- W4236304019 creator A5066095580 @default.
- W4236304019 creator A5067770341 @default.
- W4236304019 creator A5073284827 @default.
- W4236304019 date "2020-09-02" @default.
- W4236304019 modified "2023-10-18" @default.
- W4236304019 title "Homocysteine during the third trimester is a risk factor for preeclampsia: A prospective study" @default.
- W4236304019 doi "https://doi.org/10.21203/rs.3.rs-30090/v2" @default.
- W4236304019 hasPublicationYear "2020" @default.
- W4236304019 type Work @default.
- W4236304019 citedByCount "0" @default.
- W4236304019 crossrefType "posted-content" @default.
- W4236304019 hasAuthorship W4236304019A5001027254 @default.
- W4236304019 hasAuthorship W4236304019A5031565242 @default.
- W4236304019 hasAuthorship W4236304019A5066095580 @default.
- W4236304019 hasAuthorship W4236304019A5067770341 @default.
- W4236304019 hasAuthorship W4236304019A5073284827 @default.
- W4236304019 hasBestOaLocation W42363040191 @default.
- W4236304019 hasConcept C104317684 @default.
- W4236304019 hasConcept C126322002 @default.
- W4236304019 hasConcept C131872663 @default.
- W4236304019 hasConcept C134018914 @default.
- W4236304019 hasConcept C135763542 @default.
- W4236304019 hasConcept C188816634 @default.
- W4236304019 hasConcept C2776523773 @default.
- W4236304019 hasConcept C2777090595 @default.
- W4236304019 hasConcept C2777218350 @default.
- W4236304019 hasConcept C2779234561 @default.
- W4236304019 hasConcept C2779750884 @default.
- W4236304019 hasConcept C29456083 @default.
- W4236304019 hasConcept C43563269 @default.
- W4236304019 hasConcept C50440223 @default.
- W4236304019 hasConcept C54355233 @default.
- W4236304019 hasConcept C55493867 @default.
- W4236304019 hasConcept C71924100 @default.
- W4236304019 hasConcept C86803240 @default.
- W4236304019 hasConceptScore W4236304019C104317684 @default.
- W4236304019 hasConceptScore W4236304019C126322002 @default.
- W4236304019 hasConceptScore W4236304019C131872663 @default.
- W4236304019 hasConceptScore W4236304019C134018914 @default.
- W4236304019 hasConceptScore W4236304019C135763542 @default.
- W4236304019 hasConceptScore W4236304019C188816634 @default.
- W4236304019 hasConceptScore W4236304019C2776523773 @default.
- W4236304019 hasConceptScore W4236304019C2777090595 @default.
- W4236304019 hasConceptScore W4236304019C2777218350 @default.
- W4236304019 hasConceptScore W4236304019C2779234561 @default.
- W4236304019 hasConceptScore W4236304019C2779750884 @default.
- W4236304019 hasConceptScore W4236304019C29456083 @default.
- W4236304019 hasConceptScore W4236304019C43563269 @default.
- W4236304019 hasConceptScore W4236304019C50440223 @default.
- W4236304019 hasConceptScore W4236304019C54355233 @default.
- W4236304019 hasConceptScore W4236304019C55493867 @default.
- W4236304019 hasConceptScore W4236304019C71924100 @default.
- W4236304019 hasConceptScore W4236304019C86803240 @default.
- W4236304019 hasLocation W42363040191 @default.
- W4236304019 hasLocation W42363040192 @default.
- W4236304019 hasOpenAccess W4236304019 @default.
- W4236304019 hasPrimaryLocation W42363040191 @default.
- W4236304019 hasRelatedWork W10451342 @default.
- W4236304019 hasRelatedWork W1424066 @default.
- W4236304019 hasRelatedWork W16250231 @default.
- W4236304019 hasRelatedWork W18311746 @default.
- W4236304019 hasRelatedWork W1883106 @default.
- W4236304019 hasRelatedWork W19183810 @default.
- W4236304019 hasRelatedWork W6849135 @default.
- W4236304019 hasRelatedWork W7061706 @default.
- W4236304019 hasRelatedWork W8859793 @default.
- W4236304019 hasRelatedWork W9858981 @default.
- W4236304019 isParatext "false" @default.
- W4236304019 isRetracted "false" @default.
- W4236304019 workType "article" @default.