Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236389299> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4236389299 abstract "Metformin is becoming a popular treatment before and during pregnancy but current literature on <i>in utero</i> exposure to metformin lacks long-term clinical trials and mechanistic studies. Current literature on the effects of metformin on mature pancreatic β cells highlighted its dual, opposing, protective or inhibitory, effects depending on metabolic environments. However, the impact of metformin on developing human pancreatic β cells remains unknown. Here, we investigated the potential effects of metformin exposure on human pancreatic β cell development and function <i>in vitro</i>. In the absence of metabolic challenges such as high levels of glucose and fatty acids, metformin exposure impaired the development and function of pancreatic β cells, with downregulation of pancreatic genes and dysfunctional mitochondrial respiration. It also affected the insulin secretion function of pancreatic β cells. These findings call for further in-depth evaluation of the exposure of human embryonic and fetal tissue during pregnancy to metformin, and its implications on long-term offspring health." @default.
- W4236389299 created "2022-05-12" @default.
- W4236389299 creator A5013087727 @default.
- W4236389299 creator A5034891259 @default.
- W4236389299 creator A5055424683 @default.
- W4236389299 creator A5063986591 @default.
- W4236389299 creator A5072349549 @default.
- W4236389299 creator A5074092331 @default.
- W4236389299 creator A5079670138 @default.
- W4236389299 date "2021-05-06" @default.
- W4236389299 modified "2023-10-18" @default.
- W4236389299 title "Metformin Perturbs Pancreatic Differentiation from Human Embryonic Stem Cells" @default.
- W4236389299 doi "https://doi.org/10.2337/figshare.14538108" @default.
- W4236389299 hasPublicationYear "2021" @default.
- W4236389299 type Work @default.
- W4236389299 citedByCount "0" @default.
- W4236389299 crossrefType "posted-content" @default.
- W4236389299 hasAuthorship W4236389299A5013087727 @default.
- W4236389299 hasAuthorship W4236389299A5034891259 @default.
- W4236389299 hasAuthorship W4236389299A5055424683 @default.
- W4236389299 hasAuthorship W4236389299A5063986591 @default.
- W4236389299 hasAuthorship W4236389299A5072349549 @default.
- W4236389299 hasAuthorship W4236389299A5074092331 @default.
- W4236389299 hasAuthorship W4236389299A5079670138 @default.
- W4236389299 hasBestOaLocation W42363892991 @default.
- W4236389299 hasConcept C104317684 @default.
- W4236389299 hasConcept C112672928 @default.
- W4236389299 hasConcept C126322002 @default.
- W4236389299 hasConcept C134018914 @default.
- W4236389299 hasConcept C145103041 @default.
- W4236389299 hasConcept C2779234561 @default.
- W4236389299 hasConcept C2779306644 @default.
- W4236389299 hasConcept C2780323712 @default.
- W4236389299 hasConcept C54355233 @default.
- W4236389299 hasConcept C55493867 @default.
- W4236389299 hasConcept C71924100 @default.
- W4236389299 hasConcept C86803240 @default.
- W4236389299 hasConceptScore W4236389299C104317684 @default.
- W4236389299 hasConceptScore W4236389299C112672928 @default.
- W4236389299 hasConceptScore W4236389299C126322002 @default.
- W4236389299 hasConceptScore W4236389299C134018914 @default.
- W4236389299 hasConceptScore W4236389299C145103041 @default.
- W4236389299 hasConceptScore W4236389299C2779234561 @default.
- W4236389299 hasConceptScore W4236389299C2779306644 @default.
- W4236389299 hasConceptScore W4236389299C2780323712 @default.
- W4236389299 hasConceptScore W4236389299C54355233 @default.
- W4236389299 hasConceptScore W4236389299C55493867 @default.
- W4236389299 hasConceptScore W4236389299C71924100 @default.
- W4236389299 hasConceptScore W4236389299C86803240 @default.
- W4236389299 hasLocation W42363892991 @default.
- W4236389299 hasLocation W42363892992 @default.
- W4236389299 hasOpenAccess W4236389299 @default.
- W4236389299 hasPrimaryLocation W42363892991 @default.
- W4236389299 hasRelatedWork W1983641721 @default.
- W4236389299 hasRelatedWork W1996010611 @default.
- W4236389299 hasRelatedWork W2009428258 @default.
- W4236389299 hasRelatedWork W2033313326 @default.
- W4236389299 hasRelatedWork W2064652474 @default.
- W4236389299 hasRelatedWork W2072752555 @default.
- W4236389299 hasRelatedWork W2110681150 @default.
- W4236389299 hasRelatedWork W2127828366 @default.
- W4236389299 hasRelatedWork W2744240433 @default.
- W4236389299 hasRelatedWork W3160140598 @default.
- W4236389299 isParatext "false" @default.
- W4236389299 isRetracted "false" @default.
- W4236389299 workType "article" @default.