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• W4236405194 abstract "Clinical trials of some anti-amyloid treatments have shown increased risks of cerebral microhemorrhages (MCHs) in individuals with Alzheimer disease. These are detectable with gradient-echo (GRE) MR imaging sequences and are part of the constellation of findings defined as amyloid-related imaging abnormalities (ARIA) for which the FDA has recommended monitoring during trials. The presence of 5 or more MCHs has been suggested as a criteria of exclusion from trials. Our aim was to investigate the prevalence of MCHs and their evolution with the disease process in individuals at risk for autosomal dominant Alzheimer disease (ADAD). Non-mutation carriers (NC, n=58, age=40.6±9.7years) and mutation carriers (MC, n=108, age=41.6±9.5years) underwent GRE MR sequences to detect MCH. All individuals had at least 2 imaging visits spaced by 1.9±1.1years. MCH number, siderosis, and macroscopic hemorrhages were visually quantified on each scan. Longitudinal analysis were performed to characterize the pattern of progression of MCHs with the mutation type, estimated year to symptom onset (EYO) for asymptomatic participants, and dementia using clinical dementia rating (CDR). MCH were observed in 19 participants (11%), 18 of whom were MCs (PSEN1=13, PSEN2=1 and APP=4). For all participants with MCH at baseline, the rate of increase per year was 0 for NCs and 0.88±3.66 for MCs overall, but 7.05±3.04 MCHs per year for 13 participants with 2 MCHs or more at baseline (mutation type was unassociated with rate of increase, (Figure 1).). In MCs, the increased rate per year was higher once past the estimated symptom onset (EYO>0, p<0.0005) and when they were cognitively impaired (CDR>0, p<0.005) (Figure 2). Siderosis was detected in participants with (n=3) or without (n=2) MCH. Macrohemorrhages were present only in 2 participants with MCHs within the APPmutation type and could not be directly correlated with the presence of MCHs." @default.
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• W4236405194 date "2017-07-01" @default.
• W4236405194 modified "2023-09-27" @default.
• W4236405194 title "CLINICAL RISK RELATED TO CEREBRAL MICROHEMORRHAGES IN AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE: LONGITUDINAL RESULTS FROM THE DIAN STUDY" @default.
• W4236405194 doi "https://doi.org/10.1016/j.jalz.2017.07.042" @default.
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