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- W4236474908 abstract "Chinese hamster (Don) cells resistant to 5-fluorodeoxyuridine (FUdR) have been isolated using a two-step selection procedure. In the first selection step, a line resistant to 1 μg/ml FUdR, designated D12/2, was obtained. From these cells, a second line, D3B6, resistant to 25 μg/ml FUdR was selected. Both D12/2 and D3B6 show little incorporation of [3H]TdR into TCA-insoluble material compared with Don, as measured by direct scintillation counting and by autoradiography of [3H]TdR-labelled cultures. Thymidine kinase (TK) activities of D3B6 and D12/2 are < 1% and 1.8%, respectively, of the Don value. HAT-resistant cells were obtained at a frequency of 1 × 10−3 from D12/2 and at 1 × 10−5 from D3B6. The HAT-resistant cells from D3B6 cultures show a wide range of TK activity. Reconstruction experiments provided evidence that D3B6 cells are killed by co-cultivation with Don cells in FUdR, and that this is probably due to metabolic co-operation. The modal chromosome number of both variant lines is 22. Trypsin banding studies on chromosomes of Don and D3B6 show a close similarity between the major Giemsa-stained bands in the two lines. The possible basis for the observed difference in FUdR resistance between D12/2 and D3B6 is discussed." @default.
- W4236474908 created "2022-05-12" @default.
- W4236474908 date "1973-08-01" @default.
- W4236474908 modified "2023-09-25" @default.
- W4236474908 title "Somatic crossing over in Glycine max: a new test system for environmental mutagens" @default.
- W4236474908 doi "https://doi.org/10.1016/0165-1161(73)90266-5" @default.
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