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- W4236475679 abstract "Schizophrenia is a brain disease with unknown etiology; a variety of neurodevelopmental mechanisms contribute to its pathogenesis. In this chapter, we review some of the most salient neurobiological findings that seem to be linked with the pathophysiology of psychosis generally and schizophrenia specifically. Several important findings have been made from neuroimaging and neuropathology, including reduced whole-brain volume, enlarged ventricles, and decreased cortical gray matter. Abnormalities in the prefrontal cortex, such as decreased dendritic spine density, are particularly important for cognitive and negative symptoms in schizophrenia. Functional imaging suggests that patterns of activation may be closely linked to symptom clusters. We will review neurotransmitter abnormalities, especially dopamine but also glutamate and GABA, and relevant circuitry and connectivity problems related to pathology. Finally, we will discuss genetics and heritability, and the challenges of identifying relevant loci in such a complex disorder." @default.
- W4236475679 created "2022-05-12" @default.
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- W4236475679 date "2016-10-01" @default.
- W4236475679 modified "2023-09-29" @default.
- W4236475679 title "Neurobiology of Schizophrenia" @default.
- W4236475679 doi "https://doi.org/10.1093/med/9780199331505.003.0005" @default.
- W4236475679 hasPublicationYear "2016" @default.
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