FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236501138> ?p ?o ?g. }

• W4236501138 abstract "Abstract Background In absence of effective and safe vaccines or drugs against mosquito-borne arboviral diseases (such as dengue, Zika and Rift Valley and West Nile), there have been an increasing pattern of insecticide use against the mosquito vectors of these diseases in integrated vector management (IVM) programs in Saudi Arabia. However, the efficacy of IVM programmes is threatened by the development of insecticide resistance in vectors. Gene mutations on target sites can be a valuable reference to the status of insecticide resistance. Jeddah, a global commercial and major port-of-entry city, is bearing the most (> 70%) dengue disease burden and the population of the dengue vector Aedes aegypti in Saudi Arabia. Culex quinquefasciatus is a second example as one of the major arboviral vectors in the region and a proven vector of Rift Valley fever and wide-spread in Jeddah and the rest of the western region of Saudi Arabia. However, the status of insecticide resistance and targeted site mutations on the responsible genes are not fully characterized. Methods We randomly sampled both mosquito species, Ae. aegypti and Cx. quinquefasciatus across Jeddah by daily mosquito surveillance in 2016 to detect the resistance-associated target site mutations on the voltage gated sodium channel ( VGSC ) and acetylcholinesterase 1 ( ace-1 ) genes. Results Our findings showed that Ae. aegypti resistance-associated VGSC gene mutations revealed polymorphic mutations on the 989 (allele frequency = 65.91%), 1016 (allele frequency = 65.91%), and 1534 (allele frequency = 52.27%) sites. Additionally, we documented two types of introns between exons 20 and 21, however, the I1011M point mutation was undetected. Linkage disequilibrium associations were shown between V1016G with S989P, V1016G with F1534, and V1016G with type A intron. Furthermore, no mutation on ace-1 was identified in Ae. aegypti . In Cx. quinquefasciatus , homozygous L1014F/L1014F (95.23%) on the VGSC and heterozygous G119/G119S (100%) on ace-1 were widely distributed in the samples studied. Conclusions To the best of our knowledge, this is the first record of the intron types between exons 20 and 21 on VGSC of Ae. aegypti populations, and the first report of insecticide resistance gene mutation being present in field caught Cx. quinquefasciatus in Jeddah, Saudi Arabia. High prevalence of insecticide resistance gene mutations in local primary mosquito vector species, implies that the local Ae. aegypti mosquitoes are resistant to both pyrethroid and DDT, while the resistance to all four insecticide groups may possessed in Cx. quinquefasciatus populations. Our findings alert the urgent need to carry out a comprehensive insecticide resistance gene mutation surveillance and monitoring to guide sustained and effective IVM planning and innovative guidelines in local predominate mosquito populations and mosquito-borne disease control and elimination in Saudi Arabia." @default.
• W4236501138 created "2022-05-12" @default.
• W4236501138 creator A5009766884 @default.
• W4236501138 creator A5025968640 @default.
• W4236501138 creator A5027271527 @default.
• W4236501138 creator A5033618314 @default.
• W4236501138 creator A5041631621 @default.
• W4236501138 creator A5043484079 @default.
• W4236501138 creator A5044544424 @default.
• W4236501138 creator A5045209633 @default.
• W4236501138 creator A5069964035 @default.
• W4236501138 date "2020-05-12" @default.
• W4236501138 modified "2023-09-27" @default.
• W4236501138 title "Molecular Analysis of Targeted Insecticide Resistance Gene Mutations in field Aedes Aegypti and Culex Quinquefasciatus Mosquito Vectors of Arboviruses from Saudi Arabia" @default.
• W4236501138 doi "https://doi.org/10.21203/rs.3.rs-28170/v1" @default.
• W4236501138 hasPublicationYear "2020" @default.
• W4236501138 type Work @default.
• W4236501138 citedByCount "0" @default.
• W4236501138 crossrefType "posted-content" @default.
• W4236501138 hasAuthorship W4236501138A5009766884 @default.
• W4236501138 hasAuthorship W4236501138A5025968640 @default.
• W4236501138 hasAuthorship W4236501138A5027271527 @default.
• W4236501138 hasAuthorship W4236501138A5033618314 @default.
• W4236501138 hasAuthorship W4236501138A5041631621 @default.
• W4236501138 hasAuthorship W4236501138A5043484079 @default.
• W4236501138 hasAuthorship W4236501138A5044544424 @default.
• W4236501138 hasAuthorship W4236501138A5045209633 @default.
• W4236501138 hasAuthorship W4236501138A5069964035 @default.
• W4236501138 hasBestOaLocation W42365011381 @default.
• W4236501138 hasConcept C104317684 @default.
• W4236501138 hasConcept C159047783 @default.
• W4236501138 hasConcept C173758957 @default.
• W4236501138 hasConcept C18903297 @default.
• W4236501138 hasConcept C2522874641 @default.
• W4236501138 hasConcept C2776217558 @default.
• W4236501138 hasConcept C2777775583 @default.
• W4236501138 hasConcept C2778960357 @default.
• W4236501138 hasConcept C2779518617 @default.
• W4236501138 hasConcept C2780688631 @default.
• W4236501138 hasConcept C2908647359 @default.
• W4236501138 hasConcept C40767141 @default.
• W4236501138 hasConcept C533803919 @default.
• W4236501138 hasConcept C54355233 @default.
• W4236501138 hasConcept C71924100 @default.
• W4236501138 hasConcept C86803240 @default.
• W4236501138 hasConcept C92087593 @default.
• W4236501138 hasConcept C99454951 @default.
• W4236501138 hasConceptScore W4236501138C104317684 @default.
• W4236501138 hasConceptScore W4236501138C159047783 @default.
• W4236501138 hasConceptScore W4236501138C173758957 @default.
• W4236501138 hasConceptScore W4236501138C18903297 @default.
• W4236501138 hasConceptScore W4236501138C2522874641 @default.
• W4236501138 hasConceptScore W4236501138C2776217558 @default.
• W4236501138 hasConceptScore W4236501138C2777775583 @default.
• W4236501138 hasConceptScore W4236501138C2778960357 @default.
• W4236501138 hasConceptScore W4236501138C2779518617 @default.
• W4236501138 hasConceptScore W4236501138C2780688631 @default.
• W4236501138 hasConceptScore W4236501138C2908647359 @default.
• W4236501138 hasConceptScore W4236501138C40767141 @default.
• W4236501138 hasConceptScore W4236501138C533803919 @default.
• W4236501138 hasConceptScore W4236501138C54355233 @default.
• W4236501138 hasConceptScore W4236501138C71924100 @default.
• W4236501138 hasConceptScore W4236501138C86803240 @default.
• W4236501138 hasConceptScore W4236501138C92087593 @default.
• W4236501138 hasConceptScore W4236501138C99454951 @default.
• W4236501138 hasLocation W42365011381 @default.
• W4236501138 hasLocation W42365011382 @default.
• W4236501138 hasOpenAccess W4236501138 @default.
• W4236501138 hasPrimaryLocation W42365011381 @default.
• W4236501138 hasRelatedWork W11534158 @default.
• W4236501138 hasRelatedWork W13474189 @default.
• W4236501138 hasRelatedWork W15447448 @default.
• W4236501138 hasRelatedWork W17044521 @default.
• W4236501138 hasRelatedWork W25560247 @default.
• W4236501138 hasRelatedWork W26486571 @default.
• W4236501138 hasRelatedWork W31112269 @default.
• W4236501138 hasRelatedWork W31910786 @default.
• W4236501138 hasRelatedWork W36455495 @default.
• W4236501138 hasRelatedWork W35644712 @default.
• W4236501138 isParatext "false" @default.
• W4236501138 isRetracted "false" @default.
• W4236501138 workType "article" @default.