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- W4236502509 abstract "This chapter reviews the landmark breakthroughs that lead to genomic selection. First the chapter reviews the milestones in the synthesis of Mendelian and quantitative genetics. Then it reviews the early experiments of quantitative trait locus (QTL) detection using morphological and biochemical markers, beginning with Sax's landmark experiment with beans (Phaseolus vulgaris). The chapter also describes the development of DNA-level markers starting with restriction fragment length polymorphisms (RFLPs) to single nucleotide polymorphisms (SNPs) and copy number variations (CNV). Finally, it describes QTL detection and marker-assisted selection (MAS) prior to genomic selection. Unlike the morphological traits analyzed first by Mendel and then by Morgan, most traits of economic interest in agricultural species display continuous variation, rather than the discrete distribution associated with Mendelian genes. Numerous studies demonstrated that QTL affecting traits of economic importance could be detected via linkage to genetic markers." @default.
- W4236502509 created "2022-05-12" @default.
- W4236502509 date "2016-01-08" @default.
- W4236502509 modified "2023-09-23" @default.
- W4236502509 title "Historical Overview" @default.
- W4236502509 doi "https://doi.org/10.1002/9781119213628.ch1" @default.
- W4236502509 hasPublicationYear "2016" @default.
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