FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236556098> ?p ?o ?g. }

• W4236556098 endingPage "1352" @default.
• W4236556098 startingPage "1343" @default.
• W4236556098 abstract "ABSTRACT OBJECTIVE Drug-resistant epilepsy associated with hypothalamic hamartomas (HHs) can be cured by microsurgical resection of the lesions. Morbidity and mortality rates for microsurgery in this area are significant. Gamma knife surgery (GKS) is less invasive and seems to be well adapted for this indication. METHODS To evaluate the safety and efficacy of GKS to treat this uncommon pathological condition, we organized a multicenter retrospective study. Ten patients were treated in seven different centers. The follow-up periods were more than 12 months for eight patients, with a median follow-up period of 28 months (mean, 35 mo; range, 12–71 mo). All patients had severe drug-resistant epilepsy, including frequent gelastic and generalized tonic or tonicoclonic attacks. The median age was 13.5 years (range, 1–32 yr; mean, 14 yr) at the time of GKS. Three patients experienced precocious puberty. All patients had sessile HHs. The median marginal dose was 15.25 Gy (range, 12–20 Gy). Two patients were treated two times (at 19 and 49 mo) because of insufficient efficacy. RESULTS All patients exhibited improvement. Four patients were seizure-free, one experienced rare nocturnal seizures, one experienced some rare partial seizures but no more generalized attacks, and two exhibited only improvement, with reductions in the frequency of seizures but persistence of some rare generalized seizures. Two patients, now seizure-free, were considered to exhibit insufficient improvement after the first GKS procedure and were treated a second time. A clear correlation between efficacy and dose was observed in this series. The marginal dose was more than 17 Gy for all patients in the successful group and less than 13 Gy for all patients in the “improved” group. No side effects were reported, except for poikilothermia in one patient. Behavior was clearly improved for two patients (with only slight improvements in their epilepsy). Complete coverage of the HHs did not seem to be mandatory, because the dosimetry spared a significant part of the lesions for two patients in the successful group. CONCLUSION We report the first series demonstrating that GKS can be a safe and effective treatment for epilepsy related to HHs. We advocate marginal doses greater than or equal to 17 Gy and partial dose-planning when necessary, for avoidance of critical surrounding structures." @default.
• W4236556098 created "2022-05-12" @default.
• W4236556098 creator A5009336520 @default.
• W4236556098 creator A5021146440 @default.
• W4236556098 creator A5031558481 @default.
• W4236556098 creator A5035027378 @default.
• W4236556098 creator A5045867824 @default.
• W4236556098 creator A5048387742 @default.
• W4236556098 creator A5051879242 @default.
• W4236556098 creator A5060860081 @default.
• W4236556098 creator A5061867624 @default.
• W4236556098 creator A5062983106 @default.
• W4236556098 creator A5064804724 @default.
• W4236556098 creator A5068520424 @default.
• W4236556098 creator A5085368228 @default.
• W4236556098 creator A5090764517 @default.
• W4236556098 date "2000-12-01" @default.
• W4236556098 modified "2023-10-18" @default.
• W4236556098 title "Gamma Knife Surgery for Epilepsy Related to Hypothalamic Hamartomas" @default.
• W4236556098 cites W1528296748 @default.
• W4236556098 cites W1537551626 @default.
• W4236556098 cites W1964125299 @default.
• W4236556098 cites W1965895014 @default.
• W4236556098 cites W1966670679 @default.
• W4236556098 cites W1970297478 @default.
• W4236556098 cites W1990700623 @default.
• W4236556098 cites W1993854268 @default.
• W4236556098 cites W1997815981 @default.
• W4236556098 cites W2000341926 @default.
• W4236556098 cites W2002735980 @default.
• W4236556098 cites W2011481042 @default.
• W4236556098 cites W2015360450 @default.
• W4236556098 cites W2015540229 @default.
• W4236556098 cites W2018824385 @default.
• W4236556098 cites W2027970152 @default.
• W4236556098 cites W2032146895 @default.
• W4236556098 cites W2042703135 @default.
• W4236556098 cites W2055742105 @default.
• W4236556098 cites W2060649966 @default.
• W4236556098 cites W2063316723 @default.
• W4236556098 cites W2091393718 @default.
• W4236556098 cites W2109808616 @default.
• W4236556098 cites W2116317791 @default.
• W4236556098 cites W2125206535 @default.
• W4236556098 cites W2143514443 @default.
• W4236556098 cites W2144656159 @default.
• W4236556098 cites W2149861895 @default.
• W4236556098 cites W2152177012 @default.
• W4236556098 cites W2154043230 @default.
• W4236556098 cites W2154508911 @default.
• W4236556098 cites W2154940254 @default.
• W4236556098 cites W2155180159 @default.
• W4236556098 cites W2159003222 @default.
• W4236556098 cites W2166971580 @default.
• W4236556098 doi "https://doi.org/10.1097/00006123-200012000-00014" @default.
• W4236556098 hasPublicationYear "2000" @default.
• W4236556098 type Work @default.
• W4236556098 citedByCount "111" @default.
• W4236556098 countsByYear W42365560982012 @default.
• W4236556098 countsByYear W42365560982013 @default.
• W4236556098 countsByYear W42365560982014 @default.
• W4236556098 countsByYear W42365560982015 @default.
• W4236556098 countsByYear W42365560982018 @default.
• W4236556098 countsByYear W42365560982019 @default.
• W4236556098 countsByYear W42365560982020 @default.
• W4236556098 countsByYear W42365560982021 @default.
• W4236556098 countsByYear W42365560982022 @default.
• W4236556098 countsByYear W42365560982023 @default.
• W4236556098 crossrefType "journal-article" @default.
• W4236556098 hasAuthorship W4236556098A5009336520 @default.
• W4236556098 hasAuthorship W4236556098A5021146440 @default.
• W4236556098 hasAuthorship W4236556098A5031558481 @default.
• W4236556098 hasAuthorship W4236556098A5035027378 @default.
• W4236556098 hasAuthorship W4236556098A5045867824 @default.
• W4236556098 hasAuthorship W4236556098A5048387742 @default.
• W4236556098 hasAuthorship W4236556098A5051879242 @default.
• W4236556098 hasAuthorship W4236556098A5060860081 @default.
• W4236556098 hasAuthorship W4236556098A5061867624 @default.
• W4236556098 hasAuthorship W4236556098A5062983106 @default.
• W4236556098 hasAuthorship W4236556098A5064804724 @default.
• W4236556098 hasAuthorship W4236556098A5068520424 @default.
• W4236556098 hasAuthorship W4236556098A5085368228 @default.
• W4236556098 hasAuthorship W4236556098A5090764517 @default.
• W4236556098 hasConcept C118552586 @default.
• W4236556098 hasConcept C126322002 @default.
• W4236556098 hasConcept C141071460 @default.
• W4236556098 hasConcept C167135981 @default.
• W4236556098 hasConcept C187212893 @default.
• W4236556098 hasConcept C207886595 @default.
• W4236556098 hasConcept C2778186239 @default.
• W4236556098 hasConcept C2778367240 @default.
• W4236556098 hasConcept C2779449703 @default.
• W4236556098 hasConcept C2780803581 @default.
• W4236556098 hasConcept C2908900992 @default.
• W4236556098 hasConcept C71315377 @default.
• W4236556098 hasConcept C71924100 @default.
• W4236556098 hasConceptScore W4236556098C118552586 @default.
• W4236556098 hasConceptScore W4236556098C126322002 @default.

• next