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- W4236602022 abstract "This chapter discusses idiopathic juvenile osteoporosis (IJO) as a primary disease rather than the entirety of largely secondary osteoporotic conditions that may occur in young people. The etiology of IJO is unknown. More recent studies using dynamic histomorphometry showed that IJO was characterized by a markedly reduced activation frequency and therefore low remodeling activity. The typical radiographical finding in IJO is neoosseous osteoporosis, a radiolucent band at sites of newly formed metaphyseal bone. Biochemical studies of bone and mineral metabolism have not detected any consistent abnormality in children with IJO. Iliac bone biopsies show low trabecular bone volume but largely preserved core width and cortical width. The most frequent diagnostic problem facing a clinician is probably to separate IJO from OI type I. Classical IJO should only be diagnosed when vertebral compression fractures are present. Many IJO patients are probably receiving treatment with pediatric bisphosphonate therapy." @default.
- W4236602022 created "2022-05-12" @default.
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- W4236602022 date "2018-09-28" @default.
- W4236602022 modified "2023-09-25" @default.
- W4236602022 title "Juvenile Osteoporosis" @default.
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- W4236602022 doi "https://doi.org/10.1002/9781119266594.ch53" @default.
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