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- W4236662156 abstract "<h3>To the Editor.—</h3> The frequency of diagnosed<i>Mycobacterium tuberculosis</i>infection in the acquired immunodeficiency syndrome (AIDS) is escalating. The recent article by Sunderam et al<sup>1</sup>raises interesting issues regarding the relationship of these two diseases.<i>Mycobacterium tuberculosis</i>infection was shown in their study to have severe and unusual manifestations, with overwhelming extrapulmonary disease. The lack of an intact T-cell immune response in AIDS has been the commonly accepted explanation.<sup>1</sup>However, the enhanced suppressor cell activity common to both infections may play a role in the pathogenesis of these simultaneously occurring diseases. T-cell lymphopenia with a decrease in the T-helper/suppressor cell ratio occurs in untreated patients with<i>M tuberculosis</i>infection and can be reversed with therapy.<sup>2</sup>Patients with<i>M tuberculosis</i>infection who demonstrate cutaneous anergy have enhanced suppressor cell activity. In vitro, once suppressor cells are depleted, there is a 24-fold increase in T-lymphocyte response to purified protein" @default.
- W4236662156 created "2022-05-12" @default.
- W4236662156 date "1986-12-12" @default.
- W4236662156 modified "2023-09-27" @default.
- W4236662156 title "Tuberculosis as a manifestation of the acquired immunodeficiency syndrome" @default.
- W4236662156 doi "https://doi.org/10.1001/jama.256.22.3092" @default.
- W4236662156 hasPublicationYear "1986" @default.
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