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- W4236671013 abstract "Steroid 11β-hydroxylase deficiency is the second most frequent cause of congenital adrenal hyperplasia, the inherited inability to synthesize cortisol. Approximately two thirds of patients with this disorder have hypertension, presumably due to elevated levels of deoxycorticosterone or other metabolites. Signs of androgen excess also often are prominent. This disease is caused by mutations in the CYP11B1 gene, which encodes a mitochondrial cytochrome P450 enzyme. The primary treatment is glucocorticoid replacement, which suppresses excessive secretion of mineralocorticoids and androgens by the adrenal cortex." @default.
- W4236671013 created "2022-05-12" @default.
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- W4236671013 date "1994-06-01" @default.
- W4236671013 modified "2023-10-11" @default.
- W4236671013 title "Steroid 11β-Hydroxylase Deficiency and Related Disorders" @default.
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- W4236671013 doi "https://doi.org/10.1016/s0889-8529(18)30100-2" @default.
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