Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236690852> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4236690852 endingPage "75" @default.
- W4236690852 startingPage "75" @default.
- W4236690852 abstract "B cells are important effectors and regulators of adaptive and innate immune responses, inflammation and autoimmunity, for instance in anti-NMDA-receptor (NMDAR) encephalitis. Thus, pharmacological modulation of B-cell function could be an effective regimen in therapeutic strategies. Since the non-competitive NMDAR antagonist memantine is clinically applied to treat advanced Alzheimer`s disease and ketamine is supposed to improve the course of resistant depression, it is important to know how these drugs affect B-cell function. Non-competitive NMDAR antagonists impaired B-cell receptor (BCR)- and lipopolysaccharide (LPS)-induced B-cell proliferation, reduced B-cell migration towards the chemokines SDF-1α and CCL21 and downregulated IgM and IgG secretion. Mechanistically, these effects were mediated through a blockade of Kv1.3 and KCa3.1 potassium channels and resulted in an attenuated Ca2+-flux and activation of Erk1/2, Akt and NFATc1. Interestingly, NMDAR antagonist treatment increased the frequency of IL-10 producing B cells after BCR/CD40 stimulation. Non-competitive NMDAR antagonists attenuate BCR and Toll-like receptor 4 (TLR4) B-cell signaling and effector function and can foster IL-10 production. Consequently, NMDAR antagonists may be useful to target B cells in autoimmune diseases or pathological systemic inflammation. The drugs’ additional side effects on B cells should be considered in treatments of neuronal disorders with NMDAR antagonists." @default.
- W4236690852 created "2022-05-12" @default.
- W4236690852 creator A5012246833 @default.
- W4236690852 creator A5019684451 @default.
- W4236690852 creator A5029336310 @default.
- W4236690852 creator A5040557914 @default.
- W4236690852 creator A5069367651 @default.
- W4236690852 creator A5075710974 @default.
- W4236690852 creator A5087160937 @default.
- W4236690852 creator A5088006929 @default.
- W4236690852 creator A5089460733 @default.
- W4236690852 creator A5090019954 @default.
- W4236690852 date "2014-01-01" @default.
- W4236690852 modified "2023-10-06" @default.
- W4236690852 title "NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells" @default.
- W4236690852 doi "https://doi.org/10.1186/preaccept-1074437141283158" @default.
- W4236690852 hasPublicationYear "2014" @default.
- W4236690852 type Work @default.
- W4236690852 citedByCount "1" @default.
- W4236690852 countsByYear W42366908522019 @default.
- W4236690852 crossrefType "journal-article" @default.
- W4236690852 hasAuthorship W4236690852A5012246833 @default.
- W4236690852 hasAuthorship W4236690852A5019684451 @default.
- W4236690852 hasAuthorship W4236690852A5029336310 @default.
- W4236690852 hasAuthorship W4236690852A5040557914 @default.
- W4236690852 hasAuthorship W4236690852A5069367651 @default.
- W4236690852 hasAuthorship W4236690852A5075710974 @default.
- W4236690852 hasAuthorship W4236690852A5087160937 @default.
- W4236690852 hasAuthorship W4236690852A5088006929 @default.
- W4236690852 hasAuthorship W4236690852A5089460733 @default.
- W4236690852 hasAuthorship W4236690852A5090019954 @default.
- W4236690852 hasBestOaLocation W42366908521 @default.
- W4236690852 hasConcept C157695867 @default.
- W4236690852 hasConcept C159654299 @default.
- W4236690852 hasConcept C203014093 @default.
- W4236690852 hasConcept C2778453870 @default.
- W4236690852 hasConcept C86803240 @default.
- W4236690852 hasConcept C98274493 @default.
- W4236690852 hasConceptScore W4236690852C157695867 @default.
- W4236690852 hasConceptScore W4236690852C159654299 @default.
- W4236690852 hasConceptScore W4236690852C203014093 @default.
- W4236690852 hasConceptScore W4236690852C2778453870 @default.
- W4236690852 hasConceptScore W4236690852C86803240 @default.
- W4236690852 hasConceptScore W4236690852C98274493 @default.
- W4236690852 hasIssue "1" @default.
- W4236690852 hasLocation W42366908521 @default.
- W4236690852 hasLocation W42366908522 @default.
- W4236690852 hasLocation W42366908523 @default.
- W4236690852 hasOpenAccess W4236690852 @default.
- W4236690852 hasPrimaryLocation W42366908521 @default.
- W4236690852 hasRelatedWork W1894764680 @default.
- W4236690852 hasRelatedWork W2033146950 @default.
- W4236690852 hasRelatedWork W2075130635 @default.
- W4236690852 hasRelatedWork W2083048555 @default.
- W4236690852 hasRelatedWork W2146681138 @default.
- W4236690852 hasRelatedWork W2376662458 @default.
- W4236690852 hasRelatedWork W2561896603 @default.
- W4236690852 hasRelatedWork W2622555143 @default.
- W4236690852 hasRelatedWork W3095220525 @default.
- W4236690852 hasRelatedWork W3169227087 @default.
- W4236690852 hasVolume "12" @default.
- W4236690852 isParatext "false" @default.
- W4236690852 isRetracted "false" @default.
- W4236690852 workType "article" @default.