Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236693088> ?p ?o ?g. }
Showing items 1 to 47 of
47
with 100 items per page.
- W4236693088 abstract "Angewandte Chemie International Edition in EnglishVolume 36, Issue 13-14 Cover PictureFree Access Cover Picture (Angew. Chem. Int. Ed. Engl. 13/14/1997) First published: August 4, 1997 https://doi.org/10.1002/anie.199713591AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The cover picture shows the complex of the MeIle11 (yellow) variant of the immunosuppressive drug cyclosporin A (CsA, orange) bound to the protein cyclophilin (CyP, represented as a gray ribbon except for three protein residues in pink that make close contacts with MeIle11 (Phe113, Phe60, Met61)). The structure including the water molecules comes from Monte Carlo simulations by A. C. Pierce and W. L. Jorgensen, which have been used to study the energetic and structural effects of introducing “bumps” and “holes” into the complex. The left inset shows a surface rendering of the MeIle11 in contact with the three pink residues of CyP. The right inset shows that mutation of Phe113 to Ala opens a hole to accommodate the MeIle11 side chain better; two water molecules also enter the cavity. More about these studies is reported on pages 1466ff. The picture was generated by Dr. E. M. Duffy with the Sybyl (Tripos Associates, Inc.) and ChemEdit (D. Lim, Yale University) programs. Volume36, Issue13-14August 4, 1997 RelatedInformation" @default.
- W4236693088 created "2022-05-12" @default.
- W4236693088 date "1997-08-04" @default.
- W4236693088 modified "2023-09-27" @default.
- W4236693088 title "Cover Picture(Angew. Chem. Int. Ed. Engl. 13/14/1997)" @default.
- W4236693088 doi "https://doi.org/10.1002/anie.199713591" @default.
- W4236693088 hasPublicationYear "1997" @default.
- W4236693088 type Work @default.
- W4236693088 citedByCount "0" @default.
- W4236693088 crossrefType "other" @default.
- W4236693088 hasBestOaLocation W42366930881 @default.
- W4236693088 hasConcept C121332964 @default.
- W4236693088 hasConcept C121684516 @default.
- W4236693088 hasConcept C142362112 @default.
- W4236693088 hasConcept C161191863 @default.
- W4236693088 hasConcept C185592680 @default.
- W4236693088 hasConcept C41008148 @default.
- W4236693088 hasConcept C52119013 @default.
- W4236693088 hasConcept C71240020 @default.
- W4236693088 hasConcept C8010536 @default.
- W4236693088 hasConceptScore W4236693088C121332964 @default.
- W4236693088 hasConceptScore W4236693088C121684516 @default.
- W4236693088 hasConceptScore W4236693088C142362112 @default.
- W4236693088 hasConceptScore W4236693088C161191863 @default.
- W4236693088 hasConceptScore W4236693088C185592680 @default.
- W4236693088 hasConceptScore W4236693088C41008148 @default.
- W4236693088 hasConceptScore W4236693088C52119013 @default.
- W4236693088 hasConceptScore W4236693088C71240020 @default.
- W4236693088 hasConceptScore W4236693088C8010536 @default.
- W4236693088 hasIssue "13-14" @default.
- W4236693088 hasLocation W42366930881 @default.
- W4236693088 hasOpenAccess W4236693088 @default.
- W4236693088 hasPrimaryLocation W42366930881 @default.
- W4236693088 hasRelatedWork W1531601525 @default.
- W4236693088 hasRelatedWork W2319480705 @default.
- W4236693088 hasRelatedWork W2384464875 @default.
- W4236693088 hasRelatedWork W2606230654 @default.
- W4236693088 hasRelatedWork W2607424097 @default.
- W4236693088 hasRelatedWork W2748952813 @default.
- W4236693088 hasRelatedWork W2899084033 @default.
- W4236693088 hasRelatedWork W2948807893 @default.
- W4236693088 hasRelatedWork W4246418678 @default.
- W4236693088 hasRelatedWork W2778153218 @default.
- W4236693088 hasVolume "36" @default.
- W4236693088 isParatext "true" @default.
- W4236693088 isRetracted "false" @default.
- W4236693088 workType "paratext" @default.