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• W4236693431 abstract "Purpose/ObjectiveTo evaluate the feasibility of extracranial radiosurgery/radiotherapy by means of the CyberKnife (Accuray Inc., Sunnyvale, CA) and to compare treatment plans with the correspondent plans generated for Intensity Modulated Radiotherapy (IMRT).Materials/MethodsTen patients were treated for extracranial lesions (7 lung, 1 pancreas and 2 liver) by means of the CyberKnife. Volume of the lesions ranged from 22.1 cc to 584.4 cc (mean value: 184.99 cc). The doses prescribed were 20–30 Gy at the maximum, with a mean value of 26.4 Gy, in 1–3 fractions. All the treatment plans were generated requiring that the 80% isodose surface completely encompassed the target volume. A non-isocentric, conformal technique has been used for all treatments. Dose constraints were assigned to organs at risk in the proximity of the target.The IMRT treatment plans were calculated to obtain the same coverage of the target and with the same constraints to organs at risk. A step-and-shoot technique was employed, based on a Primus 6MV accelerator (Siemens Medical Solutions, Malvern, PA). The treatment plans were generated by means of the Pinnacle3 treatment planning system (Philips Medical Systems, Best, The Netherlands).We evaluated the plans by comparing homogeneity and conformity indexes. The ratio between the volume of any isodose surface to the volume of the reference isodose surface was also calculated and reported graphically (fig.1).ResultsThe homogeneity index ranged from 1.35 to 1.69 (mean 1.51) for the CyberKnife and from 1.16 to 1.64 (mean 1.43) for IMRT. The conformity index ranged from 0.81 to 1.28 (mean 0.93) for the CyberKnife and from 0.79 to 2.20 (mean 1.47) for IMRT. The ratio between isodose volumes ranged from 2.58 to 4.29 (mean 3.20) at the 50% isodose level for the CyberKnife and from 3.09 to 4.45 (mean 3.71) for IMRT. At the 20% isodose level values ranged from 5.15 to 10.45 (mean 8.07) for the CyberKnife and from 12.1 to 32.56 (mean 18.68) for IMRT.Conclusions Purpose/ObjectiveTo evaluate the feasibility of extracranial radiosurgery/radiotherapy by means of the CyberKnife (Accuray Inc., Sunnyvale, CA) and to compare treatment plans with the correspondent plans generated for Intensity Modulated Radiotherapy (IMRT). To evaluate the feasibility of extracranial radiosurgery/radiotherapy by means of the CyberKnife (Accuray Inc., Sunnyvale, CA) and to compare treatment plans with the correspondent plans generated for Intensity Modulated Radiotherapy (IMRT). Materials/MethodsTen patients were treated for extracranial lesions (7 lung, 1 pancreas and 2 liver) by means of the CyberKnife. Volume of the lesions ranged from 22.1 cc to 584.4 cc (mean value: 184.99 cc). The doses prescribed were 20–30 Gy at the maximum, with a mean value of 26.4 Gy, in 1–3 fractions. All the treatment plans were generated requiring that the 80% isodose surface completely encompassed the target volume. A non-isocentric, conformal technique has been used for all treatments. Dose constraints were assigned to organs at risk in the proximity of the target.The IMRT treatment plans were calculated to obtain the same coverage of the target and with the same constraints to organs at risk. A step-and-shoot technique was employed, based on a Primus 6MV accelerator (Siemens Medical Solutions, Malvern, PA). The treatment plans were generated by means of the Pinnacle3 treatment planning system (Philips Medical Systems, Best, The Netherlands).We evaluated the plans by comparing homogeneity and conformity indexes. The ratio between the volume of any isodose surface to the volume of the reference isodose surface was also calculated and reported graphically (fig.1). Ten patients were treated for extracranial lesions (7 lung, 1 pancreas and 2 liver) by means of the CyberKnife. Volume of the lesions ranged from 22.1 cc to 584.4 cc (mean value: 184.99 cc). The doses prescribed were 20–30 Gy at the maximum, with a mean value of 26.4 Gy, in 1–3 fractions. All the treatment plans were generated requiring that the 80% isodose surface completely encompassed the target volume. A non-isocentric, conformal technique has been used for all treatments. Dose constraints were assigned to organs at risk in the proximity of the target. The IMRT treatment plans were calculated to obtain the same coverage of the target and with the same constraints to organs at risk. A step-and-shoot technique was employed, based on a Primus 6MV accelerator (Siemens Medical Solutions, Malvern, PA). The treatment plans were generated by means of the Pinnacle3 treatment planning system (Philips Medical Systems, Best, The Netherlands). We evaluated the plans by comparing homogeneity and conformity indexes. The ratio between the volume of any isodose surface to the volume of the reference isodose surface was also calculated and reported graphically (fig.1). ResultsThe homogeneity index ranged from 1.35 to 1.69 (mean 1.51) for the CyberKnife and from 1.16 to 1.64 (mean 1.43) for IMRT. The conformity index ranged from 0.81 to 1.28 (mean 0.93) for the CyberKnife and from 0.79 to 2.20 (mean 1.47) for IMRT. The ratio between isodose volumes ranged from 2.58 to 4.29 (mean 3.20) at the 50% isodose level for the CyberKnife and from 3.09 to 4.45 (mean 3.71) for IMRT. At the 20% isodose level values ranged from 5.15 to 10.45 (mean 8.07) for the CyberKnife and from 12.1 to 32.56 (mean 18.68) for IMRT. The homogeneity index ranged from 1.35 to 1.69 (mean 1.51) for the CyberKnife and from 1.16 to 1.64 (mean 1.43) for IMRT. The conformity index ranged from 0.81 to 1.28 (mean 0.93) for the CyberKnife and from 0.79 to 2.20 (mean 1.47) for IMRT. The ratio between isodose volumes ranged from 2.58 to 4.29 (mean 3.20) at the 50% isodose level for the CyberKnife and from 3.09 to 4.45 (mean 3.71) for IMRT. At the 20% isodose level values ranged from 5.15 to 10.45 (mean 8.07) for the CyberKnife and from 12.1 to 32.56 (mean 18.68) for IMRT. Conclusions" @default.
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• W4236693431 title "Cyberknife extracranial radiosurgery: A comparison with step and shoot IMRT" @default.
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