Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236698899> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4236698899 endingPage "1538" @default.
- W4236698899 startingPage "1538" @default.
- W4236698899 abstract "The hydrophilic bile salt ursodeoxycholate (UDC) improves cholesta-sis in several liver diseases and is in vitro an efficient membrane stabilizer. However, its action on chronic ethanol-induced liver damage is not established. We thus sought to determine the effect of UDC on chronic ethanol-induced steatosis and on liver plasma membrane fluidity in rats. Male rats were pair-fed liquid diets containing 36% of calories as ethanol (alcohol diet) or an isocaloric maltose-dextrin mixture (control diet). Four groups of 10 animals received, respectively, during 30 days: the control diet, the control diet + UDC (90 mg/kg/day), the alcohol diet, and the alcohol diet + UDC. Bile was collected for assessment of bile flow, biliary lipids, and individual bile salts. Liver lipid contents and lipid peroxidation were determined. Plasma membrane fluidity was assessed by fluorescence polarization of various probes. Alcohol treatment caused a 4-fold increase in liver triacylglycerol and cholesterol ester levels. UDC supplementation significantly reduced these increases by 50% and 40%, respectively. UDC intake was associated with a marked decrease in alcohol-induced lipid peroxidation. Bile flow, bile salt, and phosphor-lipid secretion were slightly increased by alcohol intake. The addition of UDC-enriched bile with tauroursodeoxycholate (38%) without significantly affecting the biliary parameters. Lastly, UDC treatment almost totally prevented the 20% increase in liver plasma membrane fluidity due to chronic alcohol intake. This study shows that UDC intake, concomitant with alcohol diet, exerts a clear-cut membrane protective effect that might alleviate ethanol-induced lipid disorders." @default.
- W4236698899 created "2022-05-12" @default.
- W4236698899 creator A5006338160 @default.
- W4236698899 creator A5017533962 @default.
- W4236698899 creator A5027618633 @default.
- W4236698899 creator A5029423796 @default.
- W4236698899 creator A5050036532 @default.
- W4236698899 creator A5050185884 @default.
- W4236698899 date "1998-10-01" @default.
- W4236698899 modified "2023-09-27" @default.
- W4236698899 title "Ursodeoxycholate Alleviates Alcoholic Fatty Liver Damage in Rats" @default.
- W4236698899 doi "https://doi.org/10.1097/00000374-199810000-00025" @default.
- W4236698899 hasPublicationYear "1998" @default.
- W4236698899 type Work @default.
- W4236698899 citedByCount "0" @default.
- W4236698899 crossrefType "journal-article" @default.
- W4236698899 hasAuthorship W4236698899A5006338160 @default.
- W4236698899 hasAuthorship W4236698899A5017533962 @default.
- W4236698899 hasAuthorship W4236698899A5027618633 @default.
- W4236698899 hasAuthorship W4236698899A5029423796 @default.
- W4236698899 hasAuthorship W4236698899A5050036532 @default.
- W4236698899 hasAuthorship W4236698899A5050185884 @default.
- W4236698899 hasConcept C122398194 @default.
- W4236698899 hasConcept C126322002 @default.
- W4236698899 hasConcept C134018914 @default.
- W4236698899 hasConcept C185592680 @default.
- W4236698899 hasConcept C2776151105 @default.
- W4236698899 hasConcept C2776175330 @default.
- W4236698899 hasConcept C2776637226 @default.
- W4236698899 hasConcept C2777214474 @default.
- W4236698899 hasConcept C2777575235 @default.
- W4236698899 hasConcept C2778163477 @default.
- W4236698899 hasConcept C2778349201 @default.
- W4236698899 hasConcept C2778772119 @default.
- W4236698899 hasConcept C2779134260 @default.
- W4236698899 hasConcept C2780161600 @default.
- W4236698899 hasConcept C2780829032 @default.
- W4236698899 hasConcept C2781066024 @default.
- W4236698899 hasConcept C41625074 @default.
- W4236698899 hasConcept C55493867 @default.
- W4236698899 hasConcept C71924100 @default.
- W4236698899 hasConcept C86803240 @default.
- W4236698899 hasConceptScore W4236698899C122398194 @default.
- W4236698899 hasConceptScore W4236698899C126322002 @default.
- W4236698899 hasConceptScore W4236698899C134018914 @default.
- W4236698899 hasConceptScore W4236698899C185592680 @default.
- W4236698899 hasConceptScore W4236698899C2776151105 @default.
- W4236698899 hasConceptScore W4236698899C2776175330 @default.
- W4236698899 hasConceptScore W4236698899C2776637226 @default.
- W4236698899 hasConceptScore W4236698899C2777214474 @default.
- W4236698899 hasConceptScore W4236698899C2777575235 @default.
- W4236698899 hasConceptScore W4236698899C2778163477 @default.
- W4236698899 hasConceptScore W4236698899C2778349201 @default.
- W4236698899 hasConceptScore W4236698899C2778772119 @default.
- W4236698899 hasConceptScore W4236698899C2779134260 @default.
- W4236698899 hasConceptScore W4236698899C2780161600 @default.
- W4236698899 hasConceptScore W4236698899C2780829032 @default.
- W4236698899 hasConceptScore W4236698899C2781066024 @default.
- W4236698899 hasConceptScore W4236698899C41625074 @default.
- W4236698899 hasConceptScore W4236698899C55493867 @default.
- W4236698899 hasConceptScore W4236698899C71924100 @default.
- W4236698899 hasConceptScore W4236698899C86803240 @default.
- W4236698899 hasIssue "7" @default.
- W4236698899 hasLocation W42366988991 @default.
- W4236698899 hasOpenAccess W4236698899 @default.
- W4236698899 hasPrimaryLocation W42366988991 @default.
- W4236698899 hasRelatedWork W168481025 @default.
- W4236698899 hasRelatedWork W2037359006 @default.
- W4236698899 hasRelatedWork W2361809480 @default.
- W4236698899 hasRelatedWork W2485531636 @default.
- W4236698899 hasRelatedWork W2891823525 @default.
- W4236698899 hasRelatedWork W2981834545 @default.
- W4236698899 hasRelatedWork W3111018736 @default.
- W4236698899 hasRelatedWork W4301397851 @default.
- W4236698899 hasRelatedWork W4303648544 @default.
- W4236698899 hasRelatedWork W4312095059 @default.
- W4236698899 hasVolume "22" @default.
- W4236698899 isParatext "false" @default.
- W4236698899 isRetracted "false" @default.
- W4236698899 workType "article" @default.