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• W4236742559 abstract "Blood and skin-homing lymphocytes in adults with atopic dermatitis have telomerase erosion and increased telomerase activity of T lymphocytes, characteristics associated with malignancies of the hematopoeitic system. In addition, immunosuppressive AD therapies (UV light, tar, cyclosporine) may increase cancer risk. Olesen and colleagues studied all adults in Denmark hospitalized for AD from 1977–1996, comparing this to the Danish Cancer Register through 1996. In 2030 adult AD patients, an increased risk of cancer was observed (standard morbidity ratio=1.5 (95% CI: 1.2–1.9). Half of the malignancies were keratinocyte-derived. These hospitalized patients may be a special subset of AD and results should not be generalized. J Invest Dermatol 125:445–449, 2005. Segmental neurofibromatosis type 1 (SNF1), characterized by the limited distribution of neurofibromas and café-au-lait spots characteristic of neurofibromatosis type 1 (NF1), is attributed to mosaicism for an NF1 gene mutation. Consoli and colleagues studied the tissue distribution of this NF1 mutation in an SNF1 parent with an NF1 offspring. Using DNA cloning and allele-specific PCR, biopsies from the affected and unaffected skin of the mother showed variable levels of mosaicism for the mutation in keratinocytes and fibroblasts, whereas the authors found the heterozygous mutation in the child's lymphocyte DNA at a level readily detectable by PCR/direct sequencing. Their findings confirm that gonosomal mosaicism can occur in SNF1, with consequent important implications for genetic counseling. J Invest Dermatol 125:463–466, 2005. Over 90% of human malignancies arise from epithelial cells; thus, it is of great importance to understand the mechanisms by which these cells bypass growth arrest and become immortal. Darbro and coworkers cultured human keratinocytes, a model epithelial cell type, with fibroblast feeder cells or on plastic alone. Those grown without feeder cells had significantly increased expression of genes involved in keratinocyte migration and reduced expression of genes involved in keratinocyte differentiation. Their results suggest that under these conditions the tumor suppressor p16 is selectively induced by a mechanism involving tyrosine kinase activity and the urokinase plasminogen activation system. J Invest Dermatol 125:499-509, 2005. Ishimatsu-Tsuji and colleagues have discovered the gene expression patterns in each stage of the hair cycle in mice. Using wax depilation to synchronize the hair cycle, they focused on genes that were upregulated greater than 5-fold after hair induction. Categorizing the genes into 4 classes based on the phases of growth, regression, and rest, they identified 12 proteins (e.g., carbonic anhydrase 6, cytidine 5′-trisphosphate synthase, and cathepsin E) not previously suspected to play a role in hair biology. Clarifying the mechanisms of hair cycle regulation may help to pinpoint molecular targets for future growth and/or depilation agents. J Invest Dermatol 125:410–420, 2005." @default.
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• W4236742559 date "2005-09-01" @default.
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• W4236742559 title "Clinical Snippets" @default.
• W4236742559 doi "https://doi.org/10.1111/j.0022-202x.2005.23921.x" @default.
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