Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236874188> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4236874188 endingPage "2095" @default.
- W4236874188 startingPage "2084" @default.
- W4236874188 abstract "BACKGROUND Medullary thyroid carcinoma (MTC) belongs in the group of neuroendocrine tumors with early lymphatic and hepatic dissemination. A high rate of undetectable metastases is hypothesized to be responsible for the frequent mismatch between the apparent relatively small tumor burden and the elevated plasma tumor marker level. METHODS Thirty-six MTC patients with residual/recurrent biochemical signs (elevated basal calcitonin level) and/or characteristic general symptoms (diarrhea and/or flushing) were systematically examined by conventional radiology, whole-body 18F-deoxyglucose positron emission tomography (PET), dynamic liver computed tomography and magnetic resonance imaging, and hepatic angiography. RESULTS Conventional diagnostic imaging revealed lymph node (LN) involvement in the cervical, mediastinal, supraclavicular, and axillary regions (16 cases), and multiple pulmonary (3 cases), bony (1 solitary and 1 multiple case), and breast (1 case) metastases. 18F-deoxyglucose PET identified all these extralymphatic metastatic lesions (except 2 cases with multiple pulmonary metastases), and also supradiaphragmatic LN involvement in 34 (94%) patients. In 32 (89%) cases, multiple small (generally ≤ 1 cm) hypervascular, hepatic metastases undetectable by other imaging methods were localized angiographically. Of the 23 original pathologic specimens investigated, 18 (78%) exhibited LN involvement. The smallest primary tumor in patients with hepatic metastases was 1 cm. CONCLUSIONS Hepatic angiography is recommended for primary staging in MTC patients with a primary tumor measuring 1 cm or larger, and/or pathologically proven LN involvement, and also during restaging for suspected recurrences to avoid unnecessary extensive surgical LN dissection in the neck and mediastinum. Cancer 2001;91:2084–95. © 2001 American Cancer Society." @default.
- W4236874188 created "2022-05-12" @default.
- W4236874188 creator A5001687495 @default.
- W4236874188 creator A5010190134 @default.
- W4236874188 creator A5012150905 @default.
- W4236874188 creator A5023069455 @default.
- W4236874188 creator A5038259322 @default.
- W4236874188 creator A5042827731 @default.
- W4236874188 creator A5055628216 @default.
- W4236874188 creator A5055987275 @default.
- W4236874188 creator A5060166979 @default.
- W4236874188 creator A5078359203 @default.
- W4236874188 creator A5081701478 @default.
- W4236874188 creator A5085626047 @default.
- W4236874188 date "2001-06-01" @default.
- W4236874188 modified "2023-10-17" @default.
- W4236874188 title "Angiography effectively supports the diagnosis of hepatic metastases in medullary thyroid carcinoma" @default.
- W4236874188 doi "https://doi.org/10.1002/1097-0142(20010601)91:11<2084::aid-cncr1236>3.3.co;2-a" @default.
- W4236874188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11391589" @default.
- W4236874188 hasPublicationYear "2001" @default.
- W4236874188 type Work @default.
- W4236874188 citedByCount "2" @default.
- W4236874188 countsByYear W42368741882017 @default.
- W4236874188 crossrefType "journal-article" @default.
- W4236874188 hasAuthorship W4236874188A5001687495 @default.
- W4236874188 hasAuthorship W4236874188A5010190134 @default.
- W4236874188 hasAuthorship W4236874188A5012150905 @default.
- W4236874188 hasAuthorship W4236874188A5023069455 @default.
- W4236874188 hasAuthorship W4236874188A5038259322 @default.
- W4236874188 hasAuthorship W4236874188A5042827731 @default.
- W4236874188 hasAuthorship W4236874188A5055628216 @default.
- W4236874188 hasAuthorship W4236874188A5055987275 @default.
- W4236874188 hasAuthorship W4236874188A5060166979 @default.
- W4236874188 hasAuthorship W4236874188A5078359203 @default.
- W4236874188 hasAuthorship W4236874188A5081701478 @default.
- W4236874188 hasAuthorship W4236874188A5085626047 @default.
- W4236874188 hasBestOaLocation W42368741881 @default.
- W4236874188 hasConcept C121608353 @default.
- W4236874188 hasConcept C126322002 @default.
- W4236874188 hasConcept C126838900 @default.
- W4236874188 hasConcept C142724271 @default.
- W4236874188 hasConcept C2779013556 @default.
- W4236874188 hasConcept C2779126056 @default.
- W4236874188 hasConcept C2780283643 @default.
- W4236874188 hasConcept C2780643987 @default.
- W4236874188 hasConcept C2780849966 @default.
- W4236874188 hasConcept C2993294228 @default.
- W4236874188 hasConcept C526584372 @default.
- W4236874188 hasConcept C71924100 @default.
- W4236874188 hasConceptScore W4236874188C121608353 @default.
- W4236874188 hasConceptScore W4236874188C126322002 @default.
- W4236874188 hasConceptScore W4236874188C126838900 @default.
- W4236874188 hasConceptScore W4236874188C142724271 @default.
- W4236874188 hasConceptScore W4236874188C2779013556 @default.
- W4236874188 hasConceptScore W4236874188C2779126056 @default.
- W4236874188 hasConceptScore W4236874188C2780283643 @default.
- W4236874188 hasConceptScore W4236874188C2780643987 @default.
- W4236874188 hasConceptScore W4236874188C2780849966 @default.
- W4236874188 hasConceptScore W4236874188C2993294228 @default.
- W4236874188 hasConceptScore W4236874188C526584372 @default.
- W4236874188 hasConceptScore W4236874188C71924100 @default.
- W4236874188 hasIssue "11" @default.
- W4236874188 hasLocation W42368741881 @default.
- W4236874188 hasLocation W42368741882 @default.
- W4236874188 hasOpenAccess W4236874188 @default.
- W4236874188 hasPrimaryLocation W42368741881 @default.
- W4236874188 hasRelatedWork W141524600 @default.
- W4236874188 hasRelatedWork W1926988225 @default.
- W4236874188 hasRelatedWork W1960864063 @default.
- W4236874188 hasRelatedWork W2055887390 @default.
- W4236874188 hasRelatedWork W2088375952 @default.
- W4236874188 hasRelatedWork W2332959809 @default.
- W4236874188 hasRelatedWork W2380990080 @default.
- W4236874188 hasRelatedWork W2385138246 @default.
- W4236874188 hasRelatedWork W2386607779 @default.
- W4236874188 hasRelatedWork W2404958749 @default.
- W4236874188 hasVolume "91" @default.
- W4236874188 isParatext "false" @default.
- W4236874188 isRetracted "false" @default.
- W4236874188 workType "article" @default.