FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236903562> ?p ?o ?g. }

• W4236903562 endingPage "565" @default.
• W4236903562 startingPage "560" @default.
• W4236903562 abstract "Previous studies in our laboratory have demonstrated the mammary-specific expression of the entire rat beta-casein gene with 3.5 kilobases (kb) of 5' and 3.0 kb of 3' DNA in transgenic mice (Lee et al., Nucleic Acids Res. 16:1027-1041, 1988). In an attempt to localize sequences that dictate this specificity, lines of transgenic mice carrying two different rat beta-casein promoter-bacterial chloramphenicol acetyltransferase (cat) fusion genes have been established. Twenty and eight lines of transgenic mice carrying two fusion genes containing either 2.3 or 0.5 kb, respectively, of 5'-flanking DNA of the rat beta-casein gene along with noncoding exon I and 0.5 kb of intron A were identified, most of which transmitted the transgenes to their offspring in a Mendelian pattern. CAT activity was detected predominantly in the lactating mammary gland of female transgenic mice but not in the male mammary fat pad. A several-hundred-fold variation in the level of cat expression was observed in the mammary gland of different lines of mice, presumably due to the site of integration of the transgenes. CAT activity was increased in the mammary gland during development from virgin to midpregnancy and lactation. Unexpectedly, the casein-cat transgenes were also expressed in the thymus of different lines of both male and female mice, in some cases at levels equivalent to those observed in the mammary gland, and in contrast to the mammary gland, CAT activity was decreased during pregnancy and lactation in the thymus. Thus, 0.5 kb of 5'-flanking DNA of the rat beta-casein gene along with noncoding exon I and 0.5 kb of intron A are sufficient to target bacterial cat gene expression to the mammary gland of lactating mice." @default.
• W4236903562 created "2022-05-12" @default.
• W4236903562 creator A5007967816 @default.
• W4236903562 creator A5086412465 @default.
• W4236903562 creator A5087196426 @default.
• W4236903562 date "1989-02-01" @default.
• W4236903562 modified "2023-10-16" @default.
• W4236903562 title "Differential Regulation of Rat β-Casein–Chloramphenicol Acetyltransferase Fusion Gene Expression in Transgenic Mice" @default.
• W4236903562 cites W1589525182 @default.
• W4236903562 cites W1597303621 @default.
• W4236903562 cites W1837711156 @default.
• W4236903562 cites W1904279590 @default.
• W4236903562 cites W1971285426 @default.
• W4236903562 cites W1973862215 @default.
• W4236903562 cites W1990367849 @default.
• W4236903562 cites W1993333697 @default.
• W4236903562 cites W1995210806 @default.
• W4236903562 cites W2002886319 @default.
• W4236903562 cites W2035847457 @default.
• W4236903562 cites W2036098607 @default.
• W4236903562 cites W2036917468 @default.
• W4236903562 cites W2041354540 @default.
• W4236903562 cites W2043187797 @default.
• W4236903562 cites W2050146824 @default.
• W4236903562 cites W2056396278 @default.
• W4236903562 cites W2058682758 @default.
• W4236903562 cites W2059577285 @default.
• W4236903562 cites W2059777622 @default.
• W4236903562 cites W2068723337 @default.
• W4236903562 cites W2081419743 @default.
• W4236903562 cites W2084773650 @default.
• W4236903562 cites W2090122012 @default.
• W4236903562 cites W2091400806 @default.
• W4236903562 cites W2418122675 @default.
• W4236903562 cites W4253663860 @default.
• W4236903562 cites W99251924 @default.
• W4236903562 cites W2614273872 @default.
• W4236903562 doi "https://doi.org/10.1128/mcb.9.2.560-565.1989" @default.
• W4236903562 hasPublicationYear "1989" @default.
• W4236903562 type Work @default.
• W4236903562 citedByCount "0" @default.
• W4236903562 crossrefType "journal-article" @default.
• W4236903562 hasAuthorship W4236903562A5007967816 @default.
• W4236903562 hasAuthorship W4236903562A5086412465 @default.
• W4236903562 hasAuthorship W4236903562A5087196426 @default.
• W4236903562 hasConcept C102230213 @default.
• W4236903562 hasConcept C104317684 @default.
• W4236903562 hasConcept C111829193 @default.
• W4236903562 hasConcept C119157956 @default.
• W4236903562 hasConcept C123894998 @default.
• W4236903562 hasConcept C141035611 @default.
• W4236903562 hasConcept C150194340 @default.
• W4236903562 hasConcept C153911025 @default.
• W4236903562 hasConcept C161733203 @default.
• W4236903562 hasConcept C165864922 @default.
• W4236903562 hasConcept C2778473333 @default.
• W4236903562 hasConcept C2779649592 @default.
• W4236903562 hasConcept C2780730277 @default.
• W4236903562 hasConcept C40767141 @default.
• W4236903562 hasConcept C523546767 @default.
• W4236903562 hasConcept C54355233 @default.
• W4236903562 hasConcept C86803240 @default.
• W4236903562 hasConceptScore W4236903562C102230213 @default.
• W4236903562 hasConceptScore W4236903562C104317684 @default.
• W4236903562 hasConceptScore W4236903562C111829193 @default.
• W4236903562 hasConceptScore W4236903562C119157956 @default.
• W4236903562 hasConceptScore W4236903562C123894998 @default.
• W4236903562 hasConceptScore W4236903562C141035611 @default.
• W4236903562 hasConceptScore W4236903562C150194340 @default.
• W4236903562 hasConceptScore W4236903562C153911025 @default.
• W4236903562 hasConceptScore W4236903562C161733203 @default.
• W4236903562 hasConceptScore W4236903562C165864922 @default.
• W4236903562 hasConceptScore W4236903562C2778473333 @default.
• W4236903562 hasConceptScore W4236903562C2779649592 @default.
• W4236903562 hasConceptScore W4236903562C2780730277 @default.
• W4236903562 hasConceptScore W4236903562C40767141 @default.
• W4236903562 hasConceptScore W4236903562C523546767 @default.
• W4236903562 hasConceptScore W4236903562C54355233 @default.
• W4236903562 hasConceptScore W4236903562C86803240 @default.
• W4236903562 hasIssue "2" @default.
• W4236903562 hasLocation W42369035621 @default.
• W4236903562 hasOpenAccess W4236903562 @default.
• W4236903562 hasPrimaryLocation W42369035621 @default.
• W4236903562 hasRelatedWork W151795848 @default.
• W4236903562 hasRelatedWork W1988660750 @default.
• W4236903562 hasRelatedWork W2029733737 @default.
• W4236903562 hasRelatedWork W2079174399 @default.
• W4236903562 hasRelatedWork W2082049692 @default.
• W4236903562 hasRelatedWork W2143108234 @default.
• W4236903562 hasRelatedWork W2149484944 @default.
• W4236903562 hasRelatedWork W2501754528 @default.
• W4236903562 hasRelatedWork W4223443460 @default.
• W4236903562 hasRelatedWork W48093827 @default.
• W4236903562 hasVolume "9" @default.
• W4236903562 isParatext "false" @default.
• W4236903562 isRetracted "false" @default.
• W4236903562 workType "article" @default.