Matches in SemOpenAlex for { <https://semopenalex.org/work/W4236937963> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4236937963 endingPage "1578" @default.
- W4236937963 startingPage "1578" @default.
- W4236937963 abstract "We thank Nickeleit et al.1 for their comment. In their response, they showed that newborn mice with murine polyomavirus (MPyV) IgG antibodies were protected against autologous MPyV infection and did not develop nephropathy, whereas naive animals exhibited very high plasma MPyV loads in plasma and tissue as well as morphologic signs of nephropathy.1 These results clearly show the role of the humoral response in protecting mice against severe polyomavirus infection. In humans, the role of antibodies in controlling BK virus (BKV) infection has been obscured by the fact that traditional tests that have been used for previous serology studies do not differentiate between different BKV genotypes.2 Recently, Buck and colleagues3 developed a method using reporter pseudoviruses on the basis of individual representatives of the different BKV genotypes that provides an accurate measure of the BKV-specific antibody response. They showed that BKV genotypes represent distinct serotypes with respect to neutralizing antibody responses.4 Using this test, we were able to shed new light on the role of the humoral response against BKV infection and nephropathy in kidney transplantation.5 Similar results have recently been reported for another polyomavirus, the JC virus, that causes opportunistic brain disease progressive multifocal leukoencephalopathy (PML).6 The authors showed that deficient humoral immunity is a common aspect of the pathogenesis of PML and that vaccination could stimulate and expand humoral immunity against JC virus, thus protecting individuals at risk from developing PML.6 Overall, these data provide strong evidence that strengthening the polyomavirus-specific humoral response by passive immunization or vaccination would be an effective antiviral preventive and/or therapeutic strategy. Disclosures None." @default.
- W4236937963 created "2022-05-12" @default.
- W4236937963 creator A5005542946 @default.
- W4236937963 creator A5027080443 @default.
- W4236937963 creator A5060821852 @default.
- W4236937963 creator A5076266774 @default.
- W4236937963 creator A5079758449 @default.
- W4236937963 date "2018-02-21" @default.
- W4236937963 modified "2023-10-18" @default.
- W4236937963 title "The Authors Reply" @default.
- W4236937963 cites W1989953466 @default.
- W4236937963 cites W2107507307 @default.
- W4236937963 cites W2142362267 @default.
- W4236937963 cites W2202821932 @default.
- W4236937963 cites W2765774930 @default.
- W4236937963 cites W2788799396 @default.
- W4236937963 doi "https://doi.org/10.1681/asn.2018010027" @default.
- W4236937963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29467142" @default.
- W4236937963 hasPublicationYear "2018" @default.
- W4236937963 type Work @default.
- W4236937963 citedByCount "0" @default.
- W4236937963 crossrefType "journal-article" @default.
- W4236937963 hasAuthorship W4236937963A5005542946 @default.
- W4236937963 hasAuthorship W4236937963A5027080443 @default.
- W4236937963 hasAuthorship W4236937963A5060821852 @default.
- W4236937963 hasAuthorship W4236937963A5076266774 @default.
- W4236937963 hasAuthorship W4236937963A5079758449 @default.
- W4236937963 hasBestOaLocation W42369379631 @default.
- W4236937963 hasConcept C134018914 @default.
- W4236937963 hasConcept C159047783 @default.
- W4236937963 hasConcept C159654299 @default.
- W4236937963 hasConcept C203014093 @default.
- W4236937963 hasConcept C22070199 @default.
- W4236937963 hasConcept C2522874641 @default.
- W4236937963 hasConcept C2776548049 @default.
- W4236937963 hasConcept C2778199330 @default.
- W4236937963 hasConcept C2779150272 @default.
- W4236937963 hasConcept C2779341262 @default.
- W4236937963 hasConcept C2780091579 @default.
- W4236937963 hasConcept C2780303639 @default.
- W4236937963 hasConcept C2780644213 @default.
- W4236937963 hasConcept C2781184683 @default.
- W4236937963 hasConcept C45189115 @default.
- W4236937963 hasConcept C54355233 @default.
- W4236937963 hasConcept C555293320 @default.
- W4236937963 hasConcept C86803240 @default.
- W4236937963 hasConcept C8891405 @default.
- W4236937963 hasConceptScore W4236937963C134018914 @default.
- W4236937963 hasConceptScore W4236937963C159047783 @default.
- W4236937963 hasConceptScore W4236937963C159654299 @default.
- W4236937963 hasConceptScore W4236937963C203014093 @default.
- W4236937963 hasConceptScore W4236937963C22070199 @default.
- W4236937963 hasConceptScore W4236937963C2522874641 @default.
- W4236937963 hasConceptScore W4236937963C2776548049 @default.
- W4236937963 hasConceptScore W4236937963C2778199330 @default.
- W4236937963 hasConceptScore W4236937963C2779150272 @default.
- W4236937963 hasConceptScore W4236937963C2779341262 @default.
- W4236937963 hasConceptScore W4236937963C2780091579 @default.
- W4236937963 hasConceptScore W4236937963C2780303639 @default.
- W4236937963 hasConceptScore W4236937963C2780644213 @default.
- W4236937963 hasConceptScore W4236937963C2781184683 @default.
- W4236937963 hasConceptScore W4236937963C45189115 @default.
- W4236937963 hasConceptScore W4236937963C54355233 @default.
- W4236937963 hasConceptScore W4236937963C555293320 @default.
- W4236937963 hasConceptScore W4236937963C86803240 @default.
- W4236937963 hasConceptScore W4236937963C8891405 @default.
- W4236937963 hasIssue "5" @default.
- W4236937963 hasLocation W42369379631 @default.
- W4236937963 hasLocation W42369379632 @default.
- W4236937963 hasLocation W42369379633 @default.
- W4236937963 hasLocation W42369379634 @default.
- W4236937963 hasOpenAccess W4236937963 @default.
- W4236937963 hasPrimaryLocation W42369379631 @default.
- W4236937963 hasRelatedWork W1943449996 @default.
- W4236937963 hasRelatedWork W1980459112 @default.
- W4236937963 hasRelatedWork W1998563100 @default.
- W4236937963 hasRelatedWork W2002944754 @default.
- W4236937963 hasRelatedWork W2015664385 @default.
- W4236937963 hasRelatedWork W2140422101 @default.
- W4236937963 hasRelatedWork W2169432585 @default.
- W4236937963 hasRelatedWork W2182756377 @default.
- W4236937963 hasRelatedWork W4318754221 @default.
- W4236937963 hasRelatedWork W67137837 @default.
- W4236937963 hasVolume "29" @default.
- W4236937963 isParatext "false" @default.
- W4236937963 isRetracted "false" @default.
- W4236937963 workType "article" @default.