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• W4236967868 endingPage "3291" @default.
• W4236967868 startingPage "3283" @default.
• W4236967868 abstract "Transcriptional induction of the c-fos gene in response to epidermal growth factor stimulation is mediated in part by a ternary nucleoprotein complex within the promoter consisting of serum response factor (SRF), p62TCF/Elk-1 and the serum response element (SRE). Both SRF and p62TCF/Elk-1 contact the DNA and bind in a cooperative manner to the SRE. In this study, we demonstrate that SRF and Elk-1 interact directly in the absence of the SRE. A 30-amino-acid peptide from Elk-1 (B-box) is both necessary and sufficient to mediate protein-protein contacts with SRF. Moreover, the Elk-1 B-box is necessary to enable SRF-dependent binding of an alternative ETS domain (from the transcription factor PU.1) to the c-fos SRE. Mutations in either the Elk-1 B-box or the C-terminal half of the SRF DNA-binding domain (coreSRF) which show reduced ability to form ternary complexes also show greatly reduced protein-protein interactions in the absence of the SRE. Our results clearly demonstrate that direct protein-protein interactions between the transcription factors Elk-1 and SRF, in addition to DNA contacts, contribute to the formation of a ternary complex on the c-fos SRE. We discuss the wider applicability of our results in describing specific protein-protein interactions between short well-defined transcription factor domains." @default.
• W4236967868 created "2022-05-12" @default.
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• W4236967868 date "1994-05-01" @default.
• W4236967868 modified "2023-09-25" @default.
• W4236967868 title "The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1" @default.
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• W4236967868 doi "https://doi.org/10.1128/mcb.14.5.3283-3291.1994" @default.
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