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• W4237102572 abstract "Highly significant clinical, epidemiological and pathogenetic similarities between multiple sclerosis (MS) and nasopharyngeal sinusitis has led to the hypothesis that MS is caused by the inadvertent incorporation of the lymphatic drainage of the nasopharynx into the extracellular fluid circulation of the CNS. It has been postulated that, in response to antigenic and toxic products generated by the mucosal nasopharygeal flora, the leptomeninges and CNS parenchyma acquire the characteristics of a persistently stimulated lymphoid organ. Using an extensive panel of bacterial antibodies, tissues from exceptionally early cases, identified and classified using multifactorial cluster analysis, were screened for bacterial antigens using immunohistological methods. Anti-staphylococcal antibodies detected antigen co-locating with IgG/C3d immune complexes in pre-demyelinating and in primary lesions. The distribution of the antigen in relation to the morphogenesis of early acute MS lesions is detailed. Evidence for the intrathecal processing of staphylococcal antigen was obtained using isoelectric focusing and antigen imprinting to identify antigen-specific oligoclonal bands. Employing a combination of isoelectric focusing, western blotting and mass spectrometric analysis, evidence for the intrathecal processing of staphylococcal β-haemolysin (sphingomyelinase) was obtained using CSF from MS cases. While a myelinolytic transportable toxin may be an important component in the pathogenesis of demyelination, in oligodendrocyte apoptosis, and in deviant immune responses within the CNS, the detection of other as yet unidentified staphylococcal-positive and negative oligoclonal bands points to the involvement of a cocktail of transportable antigens leaking in a similar manner into the CNS from the paranasal sinus mucosal tissues where these molecules are conserved by the resident flora to manipulate and subvert the normal processes of local and systemic immunity. Evidence for the access of other bacterial transportables to the CNS in MS should now be sought. The presence of ‘high-output’ toxigenic bacterial strains within the nasopharyngeal flora of MS patients should also be explored. The use of tracer molecules to detect and quantify nose-to-brain transport in MS patients is clearly apposite." @default.
• W4237102572 created "2022-05-12" @default.
• W4237102572 creator A5012645864 @default.
• W4237102572 date "2013-07-01" @default.
• W4237102572 modified "2023-09-30" @default.
• W4237102572 title "Staphylococcal immune complexes and myelinolytic toxin in early acute multiple sclerosis lesions—An immunohistological study supported by multifactorial cluster analysis and antigen-imprint isoelectric focusing" @default.
• W4237102572 cites W1512927594 @default.
• W4237102572 cites W1936737016 @default.
• W4237102572 cites W1969196592 @default.
• W4237102572 cites W1972019763 @default.
• W4237102572 cites W1978182690 @default.
• W4237102572 cites W1979545255 @default.
• W4237102572 cites W1980921054 @default.
• W4237102572 cites W1982029510 @default.
• W4237102572 cites W1982068564 @default.
• W4237102572 cites W1987057401 @default.
• W4237102572 cites W1991204721 @default.
• W4237102572 cites W2002265763 @default.
• W4237102572 cites W2002565915 @default.
• W4237102572 cites W2003670088 @default.
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• W4237102572 cites W2021493191 @default.
• W4237102572 cites W2030667631 @default.
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• W4237102572 cites W2041052826 @default.
• W4237102572 cites W2041535834 @default.
• W4237102572 cites W2042257477 @default.
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• W4237102572 cites W2075112416 @default.
• W4237102572 cites W2076197214 @default.
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• W4237102572 cites W2089094356 @default.
• W4237102572 cites W2091258832 @default.
• W4237102572 cites W2093942918 @default.
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• W4237102572 cites W2108059723 @default.
• W4237102572 cites W2108103590 @default.
• W4237102572 cites W2108291169 @default.
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• W4237102572 cites W2138660148 @default.
• W4237102572 cites W2146802311 @default.
• W4237102572 cites W2152919759 @default.
• W4237102572 cites W2160643201 @default.
• W4237102572 cites W2165627224 @default.
• W4237102572 cites W2166681860 @default.
• W4237102572 cites W2167459498 @default.
• W4237102572 cites W2321461978 @default.
• W4237102572 cites W2335073538 @default.
• W4237102572 cites W2337555053 @default.
• W4237102572 cites W2343903424 @default.
• W4237102572 cites W4234807372 @default.
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• W4237102572 cites W4249791718 @default.
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• W4237102572 doi "https://doi.org/10.1016/j.msard.2013.01.002" @default.
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