Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237156970> ?p ?o ?g. }
- W4237156970 endingPage "2663" @default.
- W4237156970 startingPage "2653" @default.
- W4237156970 abstract "Mutations in the SRA1 or SRA3 gene eliminate the requirement for either RAS gene (RAS1 or RAS2) in Saccharomyces cerevisiae. We cloned SRA1 and SRA3 and determined their DNA sequences. SRA1 encodes the regulatory subunit of the cyclic AMP (cAMP)-dependent protein kinase and therefore is identical to REG1 and BCY1. This gene is not essential, but its deletion confers many traits: reduction of glycogen accumulation, temperature sensitivity, reduced growth rate on maltose and sucrose, inability to grow on galactose and nonfermentable carbon sources, and nitrogen starvation intolerance. SRA3 is homologous to protein kinases that phosphorylate serine and threonine and likely encodes the catalytic subunit of the cAMP-dependent protein kinase. The wild-type SRA3 gene either triplicated in the chromosome or on episomal, low-copy plasmids behaves like spontaneous dominant SRA3 mutations by suppressing ras2-530 (RAS2::LEU2 disruption), cdc25, and cdc35 mutations. These findings indicate that the yeast RAS genes are dispensable if there is constitutive cAMP-dependent protein kinase activity." @default.
- W4237156970 created "2022-05-12" @default.
- W4237156970 creator A5044693459 @default.
- W4237156970 creator A5053068950 @default.
- W4237156970 date "1987-08-01" @default.
- W4237156970 modified "2023-09-29" @default.
- W4237156970 title "Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase" @default.
- W4237156970 cites W1519192656 @default.
- W4237156970 cites W1537442027 @default.
- W4237156970 cites W1537782690 @default.
- W4237156970 cites W1543230044 @default.
- W4237156970 cites W1562281848 @default.
- W4237156970 cites W1581318482 @default.
- W4237156970 cites W1601687245 @default.
- W4237156970 cites W1606674681 @default.
- W4237156970 cites W1608390185 @default.
- W4237156970 cites W1749836265 @default.
- W4237156970 cites W1831563137 @default.
- W4237156970 cites W1958996383 @default.
- W4237156970 cites W1966320967 @default.
- W4237156970 cites W1973782344 @default.
- W4237156970 cites W1977670183 @default.
- W4237156970 cites W1978274173 @default.
- W4237156970 cites W1984075691 @default.
- W4237156970 cites W1985910275 @default.
- W4237156970 cites W1992488970 @default.
- W4237156970 cites W1998646850 @default.
- W4237156970 cites W2008014792 @default.
- W4237156970 cites W2009856702 @default.
- W4237156970 cites W2010820226 @default.
- W4237156970 cites W2022674364 @default.
- W4237156970 cites W2022752383 @default.
- W4237156970 cites W2022864103 @default.
- W4237156970 cites W2026782063 @default.
- W4237156970 cites W2029195137 @default.
- W4237156970 cites W2039077305 @default.
- W4237156970 cites W2040276985 @default.
- W4237156970 cites W2046508015 @default.
- W4237156970 cites W2047049388 @default.
- W4237156970 cites W2050200555 @default.
- W4237156970 cites W2057503560 @default.
- W4237156970 cites W2074769145 @default.
- W4237156970 cites W2077286276 @default.
- W4237156970 cites W2079791947 @default.
- W4237156970 cites W2087777628 @default.
- W4237156970 cites W2089108869 @default.
- W4237156970 cites W2089123000 @default.
- W4237156970 cites W2089835291 @default.
- W4237156970 cites W2091670176 @default.
- W4237156970 cites W2131859611 @default.
- W4237156970 cites W2137583334 @default.
- W4237156970 cites W2138270253 @default.
- W4237156970 cites W2144006797 @default.
- W4237156970 cites W2162382740 @default.
- W4237156970 cites W2182728969 @default.
- W4237156970 cites W2409484155 @default.
- W4237156970 cites W2421955228 @default.
- W4237156970 cites W4233500135 @default.
- W4237156970 cites W4252314851 @default.
- W4237156970 cites W4252973684 @default.
- W4237156970 cites W91844216 @default.
- W4237156970 doi "https://doi.org/10.1128/mcb.7.8.2653-2663.1987" @default.
- W4237156970 hasPublicationYear "1987" @default.
- W4237156970 type Work @default.
- W4237156970 citedByCount "19" @default.
- W4237156970 countsByYear W42371569702012 @default.
- W4237156970 crossrefType "journal-article" @default.
- W4237156970 hasAuthorship W4237156970A5044693459 @default.
- W4237156970 hasAuthorship W4237156970A5053068950 @default.
- W4237156970 hasConcept C104292427 @default.
- W4237156970 hasConcept C104317684 @default.
- W4237156970 hasConcept C153911025 @default.
- W4237156970 hasConcept C159479382 @default.
- W4237156970 hasConcept C16884060 @default.
- W4237156970 hasConcept C184235292 @default.
- W4237156970 hasConcept C2777576037 @default.
- W4237156970 hasConcept C55493867 @default.
- W4237156970 hasConcept C82495950 @default.
- W4237156970 hasConcept C86803240 @default.
- W4237156970 hasConcept C94734110 @default.
- W4237156970 hasConcept C97029542 @default.
- W4237156970 hasConcept C99405784 @default.
- W4237156970 hasConceptScore W4237156970C104292427 @default.
- W4237156970 hasConceptScore W4237156970C104317684 @default.
- W4237156970 hasConceptScore W4237156970C153911025 @default.
- W4237156970 hasConceptScore W4237156970C159479382 @default.
- W4237156970 hasConceptScore W4237156970C16884060 @default.
- W4237156970 hasConceptScore W4237156970C184235292 @default.
- W4237156970 hasConceptScore W4237156970C2777576037 @default.
- W4237156970 hasConceptScore W4237156970C55493867 @default.
- W4237156970 hasConceptScore W4237156970C82495950 @default.
- W4237156970 hasConceptScore W4237156970C86803240 @default.
- W4237156970 hasConceptScore W4237156970C94734110 @default.
- W4237156970 hasConceptScore W4237156970C97029542 @default.
- W4237156970 hasConceptScore W4237156970C99405784 @default.
- W4237156970 hasIssue "8" @default.
- W4237156970 hasLocation W42371569701 @default.
- W4237156970 hasOpenAccess W4237156970 @default.