FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237218839> ?p ?o ?g. }

• W4237218839 abstract "Abstract SARS-CoV-2 has affected over 9 million patients with more than 460,000 deaths in about 6 months. Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells, which are not previously reported, may provide insights on SARS-CoV-2 transmissibility and pathogenesis, and reveal targets of intervention. Here, we reported key host and viral determinants that were essential for efficient SARS-CoV-2 infection in the human lung. First, we identified heparan sulfate as an important attachment factor for SARS-CoV-2 infection. Second, we demonstrated that while cell surface sialic acids significantly restricted SARS-CoV infection, SARS-CoV-2 could largely overcome sialic acid-mediated restriction in both human lung epithelial cells and ex vivo human lung tissue explants. Third, we demonstrated that the inserted furin-like cleavage site in SARS-CoV-2 spike was required for efficient virus replication in human lung but not intestine tissues. Overall, these findings contributed to our understanding on efficient SARS-CoV-2 infection of human lungs." @default.
• W4237218839 created "2022-05-12" @default.
• W4237218839 creator A5001278923 @default.
• W4237218839 creator A5001822370 @default.
• W4237218839 creator A5003376712 @default.
• W4237218839 creator A5004946941 @default.
• W4237218839 creator A5007068246 @default.
• W4237218839 creator A5009181066 @default.
• W4237218839 creator A5010696591 @default.
• W4237218839 creator A5022616672 @default.
• W4237218839 creator A5028019271 @default.
• W4237218839 creator A5028033114 @default.
• W4237218839 creator A5029937389 @default.
• W4237218839 creator A5034244519 @default.
• W4237218839 creator A5037780259 @default.
• W4237218839 creator A5040481654 @default.
• W4237218839 creator A5043656890 @default.
• W4237218839 creator A5043764643 @default.
• W4237218839 creator A5045425589 @default.
• W4237218839 creator A5052067284 @default.
• W4237218839 creator A5061911428 @default.
• W4237218839 creator A5063764563 @default.
• W4237218839 creator A5069394692 @default.
• W4237218839 creator A5071278984 @default.
• W4237218839 creator A5075455261 @default.
• W4237218839 creator A5079531819 @default.
• W4237218839 creator A5080853242 @default.
• W4237218839 creator A5091012494 @default.
• W4237218839 date "2020-07-13" @default.
• W4237218839 modified "2023-10-14" @default.
• W4237218839 title "Host and viral determinants for efficient SARS-CoV-2 infection of the human lung" @default.
• W4237218839 doi "https://doi.org/10.21203/rs.3.rs-40123/v1" @default.
• W4237218839 hasPublicationYear "2020" @default.
• W4237218839 type Work @default.
• W4237218839 citedByCount "0" @default.
• W4237218839 crossrefType "posted-content" @default.
• W4237218839 hasAuthorship W4237218839A5001278923 @default.
• W4237218839 hasAuthorship W4237218839A5001822370 @default.
• W4237218839 hasAuthorship W4237218839A5003376712 @default.
• W4237218839 hasAuthorship W4237218839A5004946941 @default.
• W4237218839 hasAuthorship W4237218839A5007068246 @default.
• W4237218839 hasAuthorship W4237218839A5009181066 @default.
• W4237218839 hasAuthorship W4237218839A5010696591 @default.
• W4237218839 hasAuthorship W4237218839A5022616672 @default.
• W4237218839 hasAuthorship W4237218839A5028019271 @default.
• W4237218839 hasAuthorship W4237218839A5028033114 @default.
• W4237218839 hasAuthorship W4237218839A5029937389 @default.
• W4237218839 hasAuthorship W4237218839A5034244519 @default.
• W4237218839 hasAuthorship W4237218839A5037780259 @default.
• W4237218839 hasAuthorship W4237218839A5040481654 @default.
• W4237218839 hasAuthorship W4237218839A5043656890 @default.
• W4237218839 hasAuthorship W4237218839A5043764643 @default.
• W4237218839 hasAuthorship W4237218839A5045425589 @default.
• W4237218839 hasAuthorship W4237218839A5052067284 @default.
• W4237218839 hasAuthorship W4237218839A5061911428 @default.
• W4237218839 hasAuthorship W4237218839A5063764563 @default.
• W4237218839 hasAuthorship W4237218839A5069394692 @default.
• W4237218839 hasAuthorship W4237218839A5071278984 @default.
• W4237218839 hasAuthorship W4237218839A5075455261 @default.
• W4237218839 hasAuthorship W4237218839A5079531819 @default.
• W4237218839 hasAuthorship W4237218839A5080853242 @default.
• W4237218839 hasAuthorship W4237218839A5091012494 @default.
• W4237218839 hasBestOaLocation W42372188391 @default.
• W4237218839 hasConcept C126322002 @default.
• W4237218839 hasConcept C140704245 @default.
• W4237218839 hasConcept C142724271 @default.
• W4237218839 hasConcept C1491633281 @default.
• W4237218839 hasConcept C159047783 @default.
• W4237218839 hasConcept C181199279 @default.
• W4237218839 hasConcept C203014093 @default.
• W4237218839 hasConcept C2522874641 @default.
• W4237218839 hasConcept C2777265534 @default.
• W4237218839 hasConcept C2777714996 @default.
• W4237218839 hasConcept C2778041096 @default.
• W4237218839 hasConcept C2779134260 @default.
• W4237218839 hasConcept C2779744229 @default.
• W4237218839 hasConcept C2780115458 @default.
• W4237218839 hasConcept C2780942790 @default.
• W4237218839 hasConcept C3007834351 @default.
• W4237218839 hasConcept C3008058167 @default.
• W4237218839 hasConcept C524204448 @default.
• W4237218839 hasConcept C54355233 @default.
• W4237218839 hasConcept C55493867 @default.
• W4237218839 hasConcept C71924100 @default.
• W4237218839 hasConcept C81885089 @default.
• W4237218839 hasConcept C86803240 @default.
• W4237218839 hasConceptScore W4237218839C126322002 @default.
• W4237218839 hasConceptScore W4237218839C140704245 @default.
• W4237218839 hasConceptScore W4237218839C142724271 @default.
• W4237218839 hasConceptScore W4237218839C1491633281 @default.
• W4237218839 hasConceptScore W4237218839C159047783 @default.
• W4237218839 hasConceptScore W4237218839C181199279 @default.
• W4237218839 hasConceptScore W4237218839C203014093 @default.
• W4237218839 hasConceptScore W4237218839C2522874641 @default.
• W4237218839 hasConceptScore W4237218839C2777265534 @default.
• W4237218839 hasConceptScore W4237218839C2777714996 @default.
• W4237218839 hasConceptScore W4237218839C2778041096 @default.
• W4237218839 hasConceptScore W4237218839C2779134260 @default.
• W4237218839 hasConceptScore W4237218839C2779744229 @default.
• W4237218839 hasConceptScore W4237218839C2780115458 @default.

• next