FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237239211> ?p ?o ?g. }

• W4237239211 endingPage "796" @default.
• W4237239211 startingPage "785" @default.
• W4237239211 abstract "OBJECTIVE: Superparamagnetic iron oxide nanoparticle magnetic resonance imaging (MRI) contrast agents are gaining use in the central nervous system. The purpose of this study was to evaluate the imaging characteristics, distribution, time course, and neurotoxicity of the clinical agents ferumoxtran-10, ferumoxides, and ferumoxytol, and the laboratory preparation MION-46 in rat brain. METHODS: Iron oxide agents were administered by intracerebral inoculation or intraarterially after osmotic blood-brain barrier opening in normal rats and intravenously in nude rats with intracerebral tumor xenografts. Rat brains were imaged by MRI at multiple time points and then were assessed for iron histochemistry and pathological features. RESULTS: After intracerebral injection, MRI signal changes declined slowly over weeks to months. After transvascular delivery, transient (3 d) enhancement was seen with ferumoxtran-10 or ferumoxytol, whereas ferumoxides induced long-term (28 d) signal dropout. No pathological brain cell or myelin changes were detected after delivery of the clinical iron oxide agents to normal brains. In tumor models, ferumoxtran-10 enhanced one small-cell lung carcinoma intracerebral tumor, which correlated with iron staining in cells with macrophage morphological features at the tumor margin. Little enhancement was seen in two other models. CONCLUSION: These studies demonstrate the safety and efficacy of iron oxide-based MRI contrast agents in the brain and provide imaging parameters and time course data for future studies in brain tumors and neurological lesions." @default.
• W4237239211 created "2022-05-12" @default.
• W4237239211 creator A5006993112 @default.
• W4237239211 creator A5014536479 @default.
• W4237239211 creator A5027993667 @default.
• W4237239211 creator A5048805399 @default.
• W4237239211 date "2005-10-01" @default.
• W4237239211 modified "2023-10-18" @default.
• W4237239211 title "Imaging, Distribution, and Toxicity of Superparamagnetic Iron Oxide Magnetic Resonance Nanoparticles in the Rat Brain and Intracerebral Tumor" @default.
• W4237239211 cites W1963898168 @default.
• W4237239211 cites W1964801016 @default.
• W4237239211 cites W1972582749 @default.
• W4237239211 cites W1973410630 @default.
• W4237239211 cites W1992295328 @default.
• W4237239211 cites W2006793480 @default.
• W4237239211 cites W2006858976 @default.
• W4237239211 cites W2011272082 @default.
• W4237239211 cites W2022280660 @default.
• W4237239211 cites W2035238560 @default.
• W4237239211 cites W2036851552 @default.
• W4237239211 cites W2037617087 @default.
• W4237239211 cites W2043638970 @default.
• W4237239211 cites W2046863310 @default.
• W4237239211 cites W2051421116 @default.
• W4237239211 cites W2061976748 @default.
• W4237239211 cites W2074684744 @default.
• W4237239211 cites W2081854856 @default.
• W4237239211 cites W2088667180 @default.
• W4237239211 cites W2090794044 @default.
• W4237239211 cites W2090938843 @default.
• W4237239211 cites W2106302531 @default.
• W4237239211 cites W2121045793 @default.
• W4237239211 cites W2129630137 @default.
• W4237239211 cites W2136086537 @default.
• W4237239211 cites W2163465346 @default.
• W4237239211 cites W4230035716 @default.
• W4237239211 doi "https://doi.org/10.1227/01.neu.0000175731.25414.4c" @default.
• W4237239211 hasPublicationYear "2005" @default.
• W4237239211 type Work @default.
• W4237239211 citedByCount "133" @default.
• W4237239211 countsByYear W42372392112012 @default.
• W4237239211 countsByYear W42372392112013 @default.
• W4237239211 countsByYear W42372392112014 @default.
• W4237239211 countsByYear W42372392112015 @default.
• W4237239211 countsByYear W42372392112016 @default.
• W4237239211 countsByYear W42372392112017 @default.
• W4237239211 countsByYear W42372392112018 @default.
• W4237239211 countsByYear W42372392112019 @default.
• W4237239211 countsByYear W42372392112020 @default.
• W4237239211 countsByYear W42372392112021 @default.
• W4237239211 countsByYear W42372392112022 @default.
• W4237239211 countsByYear W42372392112023 @default.
• W4237239211 crossrefType "journal-article" @default.
• W4237239211 hasAuthorship W4237239211A5006993112 @default.
• W4237239211 hasAuthorship W4237239211A5014536479 @default.
• W4237239211 hasAuthorship W4237239211A5027993667 @default.
• W4237239211 hasAuthorship W4237239211A5048805399 @default.
• W4237239211 hasConcept C126322002 @default.
• W4237239211 hasConcept C126838900 @default.
• W4237239211 hasConcept C142724271 @default.
• W4237239211 hasConcept C143409427 @default.
• W4237239211 hasConcept C178790620 @default.
• W4237239211 hasConcept C185592680 @default.
• W4237239211 hasConcept C2777094939 @default.
• W4237239211 hasConcept C2777697756 @default.
• W4237239211 hasConcept C2777736543 @default.
• W4237239211 hasConcept C2778889443 @default.
• W4237239211 hasConcept C2779130545 @default.
• W4237239211 hasConcept C2909801847 @default.
• W4237239211 hasConcept C529278444 @default.
• W4237239211 hasConcept C71924100 @default.
• W4237239211 hasConceptScore W4237239211C126322002 @default.
• W4237239211 hasConceptScore W4237239211C126838900 @default.
• W4237239211 hasConceptScore W4237239211C142724271 @default.
• W4237239211 hasConceptScore W4237239211C143409427 @default.
• W4237239211 hasConceptScore W4237239211C178790620 @default.
• W4237239211 hasConceptScore W4237239211C185592680 @default.
• W4237239211 hasConceptScore W4237239211C2777094939 @default.
• W4237239211 hasConceptScore W4237239211C2777697756 @default.
• W4237239211 hasConceptScore W4237239211C2777736543 @default.
• W4237239211 hasConceptScore W4237239211C2778889443 @default.
• W4237239211 hasConceptScore W4237239211C2779130545 @default.
• W4237239211 hasConceptScore W4237239211C2909801847 @default.
• W4237239211 hasConceptScore W4237239211C529278444 @default.
• W4237239211 hasConceptScore W4237239211C71924100 @default.
• W4237239211 hasIssue "4" @default.
• W4237239211 hasLocation W42372392111 @default.
• W4237239211 hasOpenAccess W4237239211 @default.
• W4237239211 hasPrimaryLocation W42372392111 @default.
• W4237239211 hasRelatedWork W1969445930 @default.
• W4237239211 hasRelatedWork W1985421790 @default.
• W4237239211 hasRelatedWork W2044758573 @default.
• W4237239211 hasRelatedWork W2050298314 @default.
• W4237239211 hasRelatedWork W2068775994 @default.
• W4237239211 hasRelatedWork W2160843021 @default.
• W4237239211 hasRelatedWork W2286395366 @default.
• W4237239211 hasRelatedWork W4310776889 @default.
• W4237239211 hasRelatedWork W2185871878 @default.

• next