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- W4237245280 abstract "Myobloc (botulinum toxin type B; BoNT-B) is a new botulinum toxin serotype antigenically distinct from the type A toxin. It acts to block the release of acetylcholine at the neuromuscular junction, resulting in a localized paralysis when minute doses are injected. Studies in patients with cervical dystonia have shown that BoNT-B effectively reduces symptoms including pain associated with this disorder, and suggest that it may be effective in alleviating other painful syndromes, such as chronic headaches. The purpose of this open-label study was to evaluate the efficacy of BoNT-B in the treatment of patients with post-whiplash headaches. Thirty-one patients were enrolled in the study. These patients were status post-whiplash after 6 months, had headaches that were disabling after 4 weeks of injury, and were complaining of deep head pain that was radiating from the occipital to the orbital and lasting for more than 5-months duration. Patients had restriction of head flexion, rotation, and/or side bending at the top of the neck. The numeric rating scale (0–10) was used to rate the severity of symptoms. Pre-injection, most patients were at 10 on the NRS; none were below 8. Patients were injected with 1 cc BoNT-B (5000 U) divided among the suboccipital muscles (Recti capitis posteriors major and minor, obliqui capitis inferior and superior). Of the 31 patients, 22 (71%) reported improvements in their headache intensity and severity, and neck motion. Most patients were at 0–2 on the NRS post-injection. Adverse effects were minor, consisting mainly of dry mouth (40%) and pain at the injection site lasting for only a few days. The results of our study suggest that BoNT-B may be an effective agent for the treatment of post-whiplash headaches; further studies are warranted. Support of Elan Pharmaceuticals is gratefully acknowledged." @default.
- W4237245280 created "2022-05-12" @default.
- W4237245280 date "2002-06-01" @default.
- W4237245280 modified "2023-10-13" @default.
- W4237245280 title "EVALUATION OF MYOBLOC (BOTULINUM TOXIN TYPE B) IN PATIENTS WITH POST-WHIPLASH HEADACHES" @default.
- W4237245280 doi "https://doi.org/10.1046/j.1526-4637.2002.202416.x" @default.
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