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• W4237275528 startingPage "6979" @default.
• W4237275528 abstract "Abstract Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high‐pH environment. To overcome enzyme performance limitations under these conditions, a ketoreductase was evolved by a computationally and structurally aided strategy to increase cofactor stability through tighter binding." @default.
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• W4237275528 date "2018-05-03" @default.
• W4237275528 modified "2023-09-27" @default.
• W4237275528 title "Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction" @default.
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• W4237275528 doi "https://doi.org/10.1002/ange.201802791" @default.
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