FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237292593> ?p ?o ?g. }

• W4237292593 endingPage "S46" @default.
• W4237292593 startingPage "S45" @default.
• W4237292593 abstract "To investigate dosimetric predictors of laryngeal edema after radiotherapy (RT). Patients with HN-SCC treated with RT at UTMB were selected for the present study if they satisfied all the following criteria: 1. grossly uninvolved larynx; 2. no prior major surgical operation except for neck dissection; 3. treatment planning data available; 4. at least one fiberoptic examination of the larynx within 2 yrs from RT performed by a single observer. The larynx was recontoured on each planning CT by one observer as appropriate. Both the mean dose and the cumulative DVH of the larynx were extracted for each patient. Since a variety of fractionation schedules had been used, the dose was transformed into a linear quadratic equivalent one at 2 Gy per fraction assuming a α/β of 3 Gy without time factor. Subacute/late laryngeal edema was prospectively scored at each follow up examination according to the RTOG scale. Endpoint is considered grade 2+ laryngeal edema. Time to endpoint was calculated with log rank test from the date of treatment end. Univariate/multivariate analyses including various patient, tumor and treatment characteristics were run. Median follow up is 12.6 months (range: 0.4-46.7 mths). 66 patients met all the inclusion criteria. Primary tumor sites were as follows: oropharynx, 54 pts (81.8%); nasopharynx, 7 pts (10.6%); unknown, 5 pts (7.6%). Most pts (N=59, 89.4%) had been treated with whole-field IMRT, otherwise with conformal radiotherapy. The number of fiberoptic examinations within 2 yrs from RT was 231 for a median number of 3 (range:1-9) per patient. 29 (43.9%) and 3 (4.5%) patients developed grade 2 and grade 3 laryngeal edema, respectively. The actuarial incidence of grade 2+ edema at 13 months is 50.6±7%. 80% of events had been observed by 9 months. Laryngeal V30, V40, V50, V60 were significantly correlated with grade 2+ edema at univariate analysis. At multivariate analysis, V50 (continuum) and neck stage at RT (N0-x vs N+) were independent predictors of endpoint. For each percent of laryngeal volume that receives 50 Gy at 2 Gy per fraction, there is a 3% (95%CI: 1 to 4%, p<0.01) increase in the risk of grade 2+ laryngeal edema. V50 was further categorized into 4 groups according to quartile cut-offs. The correlation between the percentage of larynx receiving 50 Gy at 2 Gy per fraction and the actuarial incidence of grade 2+ edema at 13 months is reported in the figure. V50 was also strongly correlated with mean laryngeal dose (Spearman‘s rho 0.94, p<0.01). The risk of laryngeal edema is strictly related to the dose to the larynx and possibly to the neck. Mean laryngeal dose and V50 are the most important dosimetric factors. To minimize the risk of edema, V50 should be kept below 20%." @default.
• W4237292593 created "2022-05-12" @default.
• W4237292593 creator A5041331100 @default.
• W4237292593 creator A5070150983 @default.
• W4237292593 creator A5080451682 @default.
• W4237292593 creator A5086504687 @default.
• W4237292593 date "2006-11-01" @default.
• W4237292593 modified "2023-09-26" @default.
• W4237292593 title "78" @default.
• W4237292593 doi "https://doi.org/10.1016/j.ijrobp.2006.07.108" @default.
• W4237292593 hasPublicationYear "2006" @default.
• W4237292593 type Work @default.
• W4237292593 citedByCount "0" @default.
• W4237292593 crossrefType "journal-article" @default.
• W4237292593 hasAuthorship W4237292593A5041331100 @default.
• W4237292593 hasAuthorship W4237292593A5070150983 @default.
• W4237292593 hasAuthorship W4237292593A5080451682 @default.
• W4237292593 hasAuthorship W4237292593A5086504687 @default.
• W4237292593 hasBestOaLocation W42372925931 @default.
• W4237292593 hasConcept C126322002 @default.
• W4237292593 hasConcept C126838900 @default.
• W4237292593 hasConcept C141071460 @default.
• W4237292593 hasConcept C144301174 @default.
• W4237292593 hasConcept C168563851 @default.
• W4237292593 hasConcept C203092338 @default.
• W4237292593 hasConcept C2780474809 @default.
• W4237292593 hasConcept C2780886150 @default.
• W4237292593 hasConcept C2781447300 @default.
• W4237292593 hasConcept C2910317908 @default.
• W4237292593 hasConcept C2989005 @default.
• W4237292593 hasConcept C38180746 @default.
• W4237292593 hasConcept C509974204 @default.
• W4237292593 hasConcept C71924100 @default.
• W4237292593 hasConceptScore W4237292593C126322002 @default.
• W4237292593 hasConceptScore W4237292593C126838900 @default.
• W4237292593 hasConceptScore W4237292593C141071460 @default.
• W4237292593 hasConceptScore W4237292593C144301174 @default.
• W4237292593 hasConceptScore W4237292593C168563851 @default.
• W4237292593 hasConceptScore W4237292593C203092338 @default.
• W4237292593 hasConceptScore W4237292593C2780474809 @default.
• W4237292593 hasConceptScore W4237292593C2780886150 @default.
• W4237292593 hasConceptScore W4237292593C2781447300 @default.
• W4237292593 hasConceptScore W4237292593C2910317908 @default.
• W4237292593 hasConceptScore W4237292593C2989005 @default.
• W4237292593 hasConceptScore W4237292593C38180746 @default.
• W4237292593 hasConceptScore W4237292593C509974204 @default.
• W4237292593 hasConceptScore W4237292593C71924100 @default.
• W4237292593 hasIssue "3" @default.
• W4237292593 hasLocation W42372925931 @default.
• W4237292593 hasOpenAccess W4237292593 @default.
• W4237292593 hasPrimaryLocation W42372925931 @default.
• W4237292593 hasRelatedWork W1974286316 @default.
• W4237292593 hasRelatedWork W1986093144 @default.
• W4237292593 hasRelatedWork W2041057404 @default.
• W4237292593 hasRelatedWork W2072811575 @default.
• W4237292593 hasRelatedWork W2113660926 @default.
• W4237292593 hasRelatedWork W2275191777 @default.
• W4237292593 hasRelatedWork W2374223675 @default.
• W4237292593 hasRelatedWork W2410495250 @default.
• W4237292593 hasRelatedWork W2430153375 @default.
• W4237292593 hasRelatedWork W2153797383 @default.
• W4237292593 hasVolume "66" @default.
• W4237292593 isParatext "false" @default.
• W4237292593 isRetracted "false" @default.
• W4237292593 workType "article" @default.