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- W4237294384 abstract "In this double-blind, randomized study, 200 normal subjects received a three-day course of one of five treatment regimens: lincomycin hydrochloride monohydrate injection (sterile solution, 300 mg/ml) with two tablets of either placebo, a mixture of atropine sulfate and diphenoxylate hydrochloride (Lomotil), an aspirin-phenacetin-caffeine (APC) combination or the latter with codeine, or an injection of saline with two placebo tablets. Gastrointestinal irritation was most prominent in subjects receiving lincomycin with atropine-diphenoxylate and lincomycin with APC plus codeine (<i>P</i><.05). Decreased intestinal motility from atropine-diphenoxylate or codeine may increase the contact time between the lincomycin (or its metabolites) or some developing toxic substances and the mucosal epithelium. The use of atropine-diphenoxylate or codeine in treating lincomycin-induced diarrhea may be questionable. (<i>JAMA</i>235:1451-1454, 1976)" @default.
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- W4237294384 date "1976-04-05" @default.
- W4237294384 modified "2023-09-27" @default.
- W4237294384 title "Unfavorable effect of atropine-diphenoxylate (Lomotil) therapy in lincomycin-caused diarrhea" @default.
- W4237294384 doi "https://doi.org/10.1001/jama.235.14.1451" @default.
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