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- W4237355241 abstract "Our previous cytogenetic and microsatellite analyses showed a terminal deletion of chromosome 3p segments with a breakpoint region between 3p11.2 and 3p14.1 bands in 98% of non-papillary renal cell carcinomas (RCC). This breakpoint region covers approx. 20–25 cM genetic distance. Earlier, we found a higher frequency of rearrangements at chromosome 3p11.2 and have therefore now analyzed 74 sporadic and 26 VHL-associated RCCs with 6 polymorphic microsatellite markers mapped to this region. Thirty-three per cent of the breakpoints were mapped to a genetic distance of less than one-twentieth of the large breakpoint region 3pl1.2–14.1. We suggest that unstable DNA sequences at chromosome 3p11.2 serve as a genetic basis for deletions and homologous and non-homologous recombinations to remove distal 3p sequences with one copy of RCC gene(s) in different types of tumors. We have identified a YAC clone 909d5 that spans the most frequently occurring breaks between loci D3S1251, D3S1101, and D3S1552 and allows this region to be cloned. © 1996 Wiley-Liss, Inc." @default.
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- W4237355241 date "1996-12-11" @default.
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- W4237355241 title "Refining a proximal breakpoint cluster at chromosome 3p11.2 in non‐papillary renal cell carcinomas" @default.
- W4237355241 doi "https://doi.org/10.1002/(sici)1097-0215(19961211)68:6<723::aid-ijc5>3.3.co;2-h" @default.
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