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- W4237378122 abstract "Irradiation of human ovarian carcinoma cells (OVCAR 3) and myeloma cells (RPMI 8226) with graded doses of 137Cs-γ-rays led to a 35–40% increase in time-dependent apoptosis 72 hr after 6–8 Gy irradiation. Large individual variations in sensitivity to radiation-induced apoptosis were noted in human lymphocytes obtained from 5 donors. Pretreatment of OVCAR 3 and RPMI 8226 cells with 0.01 Gy increased their resistance to apoptosis after subsequent 6 Gy irradiation several hours or 48 and 72 hr later. A dose of 4 or 8 Gy given in 2 equal fractions at an interval of a few hours produced a low level of apoptosis compared to that resulting from a single administration of the same total dose. Adaptive response was demonstrated in 2 out of 3 samples of human lymphocytes isolated from different donors, and no split-dose effect for apoptosis was noted in 2 other donors. In split-dose experiments, there was no correlation between the sensitivity of cells to apoptosis and their position in the cell cycle, after the first half-dose. No G1 block was observed in irradiated cell lines. Adaptive response and split-dose effect were prevented by 3-aminobenzamide and okadaic acid which inhibit poly(ADP-ribose)polymerase and protein phosphatase, respectively. These results imply a common mechanism for acquired resistance to radiation-induced apoptosis in adaptive response and the split-dose effect. Int. J. Cancer 77:76–81, 1998.© 1998 Wiley-Liss, Inc." @default.
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- W4237378122 date "1998-07-03" @default.
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- W4237378122 title "Radiation‐induced apoptosis in human tumor cell lines: Adaptive response and split‐dose effect" @default.
- W4237378122 doi "https://doi.org/10.1002/(sici)1097-0215(19980703)77:1<76::aid-ijc13>3.3.co;2-7" @default.
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