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• W4237420424 abstract "Abstract Asymmetric total synthesis of the cyclic depsipeptide BE‐43547A 2 was achieved in 15 linear steps on a 350 mg scale in one batch. The synthesis features the highly diastereoselective construction of an α‐hydroxy‐β‐ketoamide through α‐hydroxylation with a d.r. of up to 86:1. BE‐43547A 2 significantly reduces the percentage of pancreatic cancer stem cells (PCSCs) in Panc‐1 cell cultures, and dramatically reduces the tumorsphere‐forming capability of Panc‐1 cells. An in vivo tumor‐initiation assay, a gold standard for cancer stem cell assays, confirmed that BE‐43547A 2 can abolish the tumorigenesis of Panc‐1 cells. The anti‐PCSC activity of BE‐43547A 2 could make this depsipeptide scaffold a promising starting point for discovering new PCSC‐targeting drugs." @default.
• W4237420424 created "2022-05-12" @default.
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• W4237420424 date "2017-10-24" @default.
• W4237420424 modified "2023-10-16" @default.
• W4237420424 title "Cyclic Depsipeptide BE-43547A₂ : Synthesis and Activity against Pancreatic Cancer Stem Cells" @default.
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• W4237420424 doi "https://doi.org/10.1002/ange.201709744" @default.
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