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- W4237437006 abstract "Abstract Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)‐assisted conversion of glucose into gluconic acid and toxic H 2 O 2 , a novel treatment paradigm of starving‐like therapy is developed for significant tumor‐killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H 2 O 2 can oxidize l ‐Arginine ( l ‐Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co‐delivery of GOx and l ‐Arg, a novel glucose‐responsive nanomedicine ( l ‐Arg‐HMON‐GOx) has been for the first time constructed for synergistic cancer starving‐like/gas therapy without the need of external excitation, which yields a remarkable H 2 O 2 –NO cooperative anticancer effect with minimal adverse effect." @default.
- W4237437006 created "2022-05-12" @default.
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- W4237437006 date "2016-12-09" @default.
- W4237437006 modified "2023-10-15" @default.
- W4237437006 title "Glucose‐Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving‐Like/Gas Therapy" @default.
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- W4237437006 doi "https://doi.org/10.1002/ange.201610682" @default.
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