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- W4237453693 abstract "The tight junction of epithelial cells excludes macromolecules but allows permeation of ions. However, it is not clear whether this ion-conducting property is mediated by aqueous pores or by ion channels. To investigate the permeability properties of the tight junction, we have developed paracellular ion flux assays for four major extracellular ions, Na(+), Cl(-), Ca(2+), and Mg(2+). We found that the tight junction shares biophysical properties with conventional ion channels, including size and charge selectivity, dependency of permeability on ion concentration, competition between permeant molecules, anomalous mole-fraction effects, and sensitivity to pH. Our results support the hypothesis that discrete ion channels are present at the tight junction. Unlike conventional ion channels, which mediate ion transport across lipid bilayers, the tight junction channels must orient parallel to the plane of the plasma membranes to support paracellular ion movements. This new class of paracellular-tight junction channels (PTJC) facilitates the transport of ions between separate extracellular compartments. PMID: 12609869 Funding information This work was supported by: NIDDK NIH HHS, United States Grant ID: F32 DK009796 NIGMS NIH HHS, United States Grant ID: R01 GM037751 NIDDK NIH HHS, United States Grant ID: K01 DK068397 NIGMS NIH HHS, United States Grant ID: GM18974 NIGMS NIH HHS, United States Grant ID: GM37751 NIDDK NIH HHS, United States Grant ID: DK09796-02 NIGMS NIH HHS, United States Grant ID: R01 GM018974 More Less keyboard_arrow_down" @default.
- W4237453693 created "2022-05-12" @default.
- W4237453693 creator A5068001869 @default.
- W4237453693 date "2003-03-14" @default.
- W4237453693 modified "2023-10-05" @default.
- W4237453693 title "Faculty Opinions recommendation of Paracellular ion channel at the tight junction." @default.
- W4237453693 doi "https://doi.org/10.3410/f.1012251.185921" @default.
- W4237453693 hasPublicationYear "2003" @default.
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