Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237515099> ?p ?o ?g. }
- W4237515099 endingPage "3792" @default.
- W4237515099 startingPage "3786" @default.
- W4237515099 abstract "How platelet shape change initiated by a collagen-related peptide (CRP) specific for the GPVI/FcRγ-chain complex (GPVI/FcRγ-chain) is coupled to SLP-76, phosphoinositide (PI) 3-kinase, and gelsolin is reported. As shown by video microscopy, platelets rapidly round and grow dynamic filopodial projections that rotate around the periphery of the cell after they contact a CRP-coated surface. Lamellae subsequently spread between the projections. All the actin-driven shape changes require SLP-76 expression. SLP-76 is essential for the Ca++mobilization induced by CRP, whereas PI 3-kinase only modulates it. The extension of lamellae requires net actin assembly and an exposure of actin filament barbed ends downstream of PI 3-kinase. Gelsolin expression is also required for the extension of lamellae, but not for the formation of filopodia. Altogether, the data describe the role of SLP-76 in the platelet activation initiated by GPVI/FcRγ-chain and the roles of PI 3-kinase and gelsolin in lamellae spreading." @default.
- W4237515099 created "2022-05-12" @default.
- W4237515099 creator A5009278014 @default.
- W4237515099 creator A5023521073 @default.
- W4237515099 creator A5046920161 @default.
- W4237515099 creator A5048379219 @default.
- W4237515099 creator A5061940883 @default.
- W4237515099 creator A5071191923 @default.
- W4237515099 date "2000-12-01" @default.
- W4237515099 modified "2023-09-26" @default.
- W4237515099 title "Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcRγ-chain complex" @default.
- W4237515099 cites W131135156 @default.
- W4237515099 cites W132759588 @default.
- W4237515099 cites W1567813092 @default.
- W4237515099 cites W158700254 @default.
- W4237515099 cites W1657825487 @default.
- W4237515099 cites W1658693572 @default.
- W4237515099 cites W1965802234 @default.
- W4237515099 cites W1966251842 @default.
- W4237515099 cites W1969563780 @default.
- W4237515099 cites W1975495359 @default.
- W4237515099 cites W1982641617 @default.
- W4237515099 cites W1987924572 @default.
- W4237515099 cites W2001234795 @default.
- W4237515099 cites W2002411373 @default.
- W4237515099 cites W2002943653 @default.
- W4237515099 cites W2003976708 @default.
- W4237515099 cites W2010435020 @default.
- W4237515099 cites W2015542496 @default.
- W4237515099 cites W2025827931 @default.
- W4237515099 cites W2025994996 @default.
- W4237515099 cites W2029004784 @default.
- W4237515099 cites W2043823402 @default.
- W4237515099 cites W2046726066 @default.
- W4237515099 cites W2054805783 @default.
- W4237515099 cites W2055496589 @default.
- W4237515099 cites W2057912373 @default.
- W4237515099 cites W2061988794 @default.
- W4237515099 cites W2066826486 @default.
- W4237515099 cites W2066921963 @default.
- W4237515099 cites W2071442472 @default.
- W4237515099 cites W2074113234 @default.
- W4237515099 cites W2078062453 @default.
- W4237515099 cites W2082633259 @default.
- W4237515099 cites W2084966096 @default.
- W4237515099 cites W2086955015 @default.
- W4237515099 cites W2091960651 @default.
- W4237515099 cites W2100837269 @default.
- W4237515099 cites W2113905792 @default.
- W4237515099 cites W2116922620 @default.
- W4237515099 cites W2118971976 @default.
- W4237515099 cites W2122043456 @default.
- W4237515099 cites W2141260882 @default.
- W4237515099 cites W2141542738 @default.
- W4237515099 cites W2466910581 @default.
- W4237515099 doi "https://doi.org/10.1182/blood.v96.12.3786.h8003786_3786_3792" @default.
- W4237515099 hasPublicationYear "2000" @default.
- W4237515099 type Work @default.
- W4237515099 citedByCount "3" @default.
- W4237515099 crossrefType "journal-article" @default.
- W4237515099 hasAuthorship W4237515099A5009278014 @default.
- W4237515099 hasAuthorship W4237515099A5023521073 @default.
- W4237515099 hasAuthorship W4237515099A5046920161 @default.
- W4237515099 hasAuthorship W4237515099A5048379219 @default.
- W4237515099 hasAuthorship W4237515099A5061940883 @default.
- W4237515099 hasAuthorship W4237515099A5071191923 @default.
- W4237515099 hasConcept C125705527 @default.
- W4237515099 hasConcept C184235292 @default.
- W4237515099 hasConcept C185592680 @default.
- W4237515099 hasConcept C201800478 @default.
- W4237515099 hasConcept C203014093 @default.
- W4237515099 hasConcept C2780573682 @default.
- W4237515099 hasConcept C2781322055 @default.
- W4237515099 hasConcept C3018697912 @default.
- W4237515099 hasConcept C62478195 @default.
- W4237515099 hasConcept C75217442 @default.
- W4237515099 hasConcept C80722340 @default.
- W4237515099 hasConcept C86803240 @default.
- W4237515099 hasConcept C89560881 @default.
- W4237515099 hasConcept C90301020 @default.
- W4237515099 hasConcept C95444343 @default.
- W4237515099 hasConceptScore W4237515099C125705527 @default.
- W4237515099 hasConceptScore W4237515099C184235292 @default.
- W4237515099 hasConceptScore W4237515099C185592680 @default.
- W4237515099 hasConceptScore W4237515099C201800478 @default.
- W4237515099 hasConceptScore W4237515099C203014093 @default.
- W4237515099 hasConceptScore W4237515099C2780573682 @default.
- W4237515099 hasConceptScore W4237515099C2781322055 @default.
- W4237515099 hasConceptScore W4237515099C3018697912 @default.
- W4237515099 hasConceptScore W4237515099C62478195 @default.
- W4237515099 hasConceptScore W4237515099C75217442 @default.
- W4237515099 hasConceptScore W4237515099C80722340 @default.
- W4237515099 hasConceptScore W4237515099C86803240 @default.
- W4237515099 hasConceptScore W4237515099C89560881 @default.
- W4237515099 hasConceptScore W4237515099C90301020 @default.
- W4237515099 hasConceptScore W4237515099C95444343 @default.
- W4237515099 hasIssue "12" @default.
- W4237515099 hasLocation W42375150991 @default.