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- W4237536059 abstract "• In a patient with sickle cell anemia, iron deficiency was accompanied by hypochromic, microcytic RBCs, absence of bone marrow iron, and a low serum ferritin level. The mean corpuscular hemoglobin concentration (MCHC) was decreased (27.6 g/dL) and was associated with an extreme scarcity of sickled erythrocytes in blood smears. Iron therapy resulted in reticulocytosis and an increase in sickled erythrocytes. In vitro studies demonstrated a decrease in sickling of erythrocytes as a function of oxygen saturation of the blood when the patient was iron deficient. The whole blood oxygen dissociation curve showed a substantial decrease in oxygen pressure necessary to produce 50% saturation of hemoglobin at pH 7.4 and 37 °C (<i>P</i><sub>50</sub>), indicating an increased oxygen affinity. These data suggest that a reduction of the MCHC induced by iron deficiency may ameliorate sickling. (<i>Arch Intern Med</i>1983;143:1030-1032)" @default.
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- W4237536059 date "1983-05-01" @default.
- W4237536059 modified "2023-10-03" @default.
- W4237536059 title "Iron deficiency and sickle cell anemia" @default.
- W4237536059 doi "https://doi.org/10.1001/archinte.143.5.1030" @default.
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