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- W4237567959 abstract "Thyroid hormones are modulators of cognitive functions, and changes in hormone levels affect intelligence, memory, attention and executive function. Single nucleotide polymorphisms (SNPs) of transporter proteins MCT8, MCT10 and deiodinase 2 (DIO2) influence thyroid metabolism and could therefore contribute to inter-individual variance of cognitive functions. This study investigates the influence of these SNPs using an extensive neuropsychological test battery. 656 healthy participants aged 18-39 years were genotyped for four SNPs: MCT8 (rs5937843 and rs6647476), MCT10 (rs14399) and DIO2 (rs225014) and underwent eleven different neuropsychological tests as well as four personality questionnaires. Test results were compared between homo- and heterozygous carriers and for the X-linked MCT8 additionally between men and women. Personality questionnaires revealed that Risk Seeking was reduced in homozygous T carriers and highest in homozygous C carriers of the DIO2 SNP and that both polymorphisms of MCT8 had an additive effect on Physical Aggression in men. Neuropsychological testing indicated that MCT10 affects nonverbal reasoning abilities, DIO2 influences working memory and verbal fluency and MCT8 influences attention, alertness and planning. This pilot study suggests an influence of polymorphisms in thyroid hormone transporter genes and deiodinase on cognitive domains and personality traits." @default.
- W4237567959 created "2022-05-12" @default.
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- W4237567959 date "2019-12-09" @default.
- W4237567959 modified "2023-10-17" @default.
- W4237567959 title "Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits" @default.
- W4237567959 cites W179505240 @default.
- W4237567959 cites W1964006502 @default.
- W4237567959 cites W1965462646 @default.
- W4237567959 cites W1965534308 @default.
- W4237567959 cites W1971747830 @default.
- W4237567959 cites W1974384388 @default.
- W4237567959 cites W1975345061 @default.
- W4237567959 cites W1976707420 @default.
- W4237567959 cites W1979927434 @default.
- W4237567959 cites W1989508933 @default.
- W4237567959 cites W1995651100 @default.
- W4237567959 cites W2000555003 @default.
- W4237567959 cites W2006140668 @default.
- W4237567959 cites W2008327763 @default.
- W4237567959 cites W2017632004 @default.
- W4237567959 cites W2021479552 @default.
- W4237567959 cites W2022349101 @default.
- W4237567959 cites W2028683480 @default.
- W4237567959 cites W2036671503 @default.
- W4237567959 cites W2040874072 @default.
- W4237567959 cites W2043055866 @default.
- W4237567959 cites W2045087560 @default.
- W4237567959 cites W2046152275 @default.
- W4237567959 cites W2046694106 @default.
- W4237567959 cites W2053805082 @default.
- W4237567959 cites W2055181115 @default.
- W4237567959 cites W2056254826 @default.
- W4237567959 cites W2057808752 @default.
- W4237567959 cites W2058317558 @default.
- W4237567959 cites W2060711240 @default.
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- W4237567959 cites W2072743331 @default.
- W4237567959 cites W2078333270 @default.
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- W4237567959 cites W2088566177 @default.
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- W4237567959 cites W2092277207 @default.
- W4237567959 cites W2099849362 @default.
- W4237567959 cites W2100049277 @default.
- W4237567959 cites W2101803630 @default.
- W4237567959 cites W2118039583 @default.
- W4237567959 cites W2120357670 @default.
- W4237567959 cites W2121036968 @default.
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- W4237567959 cites W2168596899 @default.
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- W4237567959 cites W2767771932 @default.
- W4237567959 cites W2767834727 @default.
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- W4237567959 doi "https://doi.org/10.1055/a-1065-1786" @default.
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