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- W4237573172 abstract "Two new N2S ligands of MPBDA (N-(2-mercapto-propyl)-1,2-benzenediamine) and MEBDA (N-(2-mercapto-ethyl)-1,2-benzenediamine) were synthesized, and their lipophilic complexes of 99mTc-MPBDA and 99mTc-MEBDA were prepared in high yield (>92%) by stannous reduction of 99mTcO4−. Effects of pH, reaction temperature and time on the formation of 99mTc complexes were investigated. Potential use of 99mTc-MPBDA and 99mTc-MEBDA in cerebral and myocardial imaging were evaluated in mice. High uptakes are demonstrated in both brain and heart, and residence times within heart are long. Two minutes following i.v. Administration, 1.85%ID of 99mTc-MPBDA and 1.49%ID of 99mTc-MEBDA appear in brain, and 1.64%ID of 99mTc-MPBDA and 1.63%ID of 99mTc-MEBDA are in heart. At 1 hr after injection, 1.17%ID and 1.26%ID of 99mTc-MPBDA remain respectively in brain and heart, and 0.67%ID and 1.18%ID of 99mTc-MEBDA remain in brain and heart respectively. The activity in blood clears rapidly and the clearance half-life is less than 15 minutes. The properties of 99mTc-MPBDA make it a potential useful agent for cerebral and myocardial perfusion imaging Copyright © 1999 John Wiley & Sons, Ltd." @default.
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- W4237573172 date "1999-07-01" @default.
- W4237573172 modified "2023-09-25" @default.
- W4237573172 title "Synthesis of new N2S ligands, preparation of 99mTc complexes and their preliminary biodistribution in mice" @default.
- W4237573172 doi "https://doi.org/10.1002/(sici)1099-1344(199907)42:7<629::aid-jlcr225>3.3.co;2-q" @default.
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