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- W4237621432 abstract "The sequence of human chromosome 18, which has the lowest gene density of any human chromosome, is now complete. Surprisingly, the proportion of non-protein-coding regions evolutionarily conserved among mammals is close to the genome-wide average. This suggests that there is more to non-coding sequences than meets the eye, and that they are well worth holding on to. Chromosome 18 appears to have the lowest gene density of any human chromosome and is one of only three chromosomes for which trisomic individuals survive to term1. There are also a number of genetic disorders stemming from chromosome 18 trisomy and aneuploidy. Here we report the finished sequence and gene annotation of human chromosome 18, which will allow a better understanding of the normal and disease biology of this chromosome. Despite the low density of protein-coding genes on chromosome 18, we find that the proportion of non-protein-coding sequences evolutionarily conserved among mammals is close to the genome-wide average. Extending this analysis to the entire human genome, we find that the density of conserved non-protein-coding sequences is largely uncorrelated with gene density. This has important implications for the nature and roles of non-protein-coding sequence elements." @default.
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- W4237621432 date "2005-09-22" @default.
- W4237621432 modified "2023-10-16" @default.
- W4237621432 title "DNA sequence and analysis of human chromosome 18" @default.
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- W4237621432 doi "https://doi.org/10.1038/nature03983" @default.
- W4237621432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16177791" @default.
- W4237621432 hasPublicationYear "2005" @default.
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