Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237632192> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4237632192 endingPage "23177" @default.
- W4237632192 startingPage "23173" @default.
- W4237632192 abstract "Abstract The enzyme 3‐methylglutaconyl coenzyme A (CoA) decarboxylase (called AibA/AibB) catalyzes the decarboxylation of 3‐methylglutaconyl CoA to generate 3,3‐dimethylacrylyl‐CoA, representing an important step in the biosynthesis of isovaleryl‐coenzyme A in Myxococcus xanthus when the regular pathway is blocked. A novel mechanism involving a pericyclic transition state has previously been proposed for this enzyme, making AibA/AibB unique among decarboxylases. Herein, density functional calculations are used to examine the energetic feasibility of this mechanism. It is shown that the intramolecular pericyclic reaction is associated with a very high energy barrier that is similar to the barrier of the same reaction in the absence of the enzyme. Instead, the calculations show that a direct decarboxylation mechanism has feasible energy barriers that are in line with the experimental observations." @default.
- W4237632192 created "2022-05-12" @default.
- W4237632192 creator A5024722452 @default.
- W4237632192 creator A5030863006 @default.
- W4237632192 date "2020-10-16" @default.
- W4237632192 modified "2023-10-18" @default.
- W4237632192 title "Mechanism of 3‐Methylglutaconyl CoA Decarboxylase AibA/AibB: Pericyclic Reaction versus Direct Decarboxylation" @default.
- W4237632192 cites W1964567061 @default.
- W4237632192 cites W1990356128 @default.
- W4237632192 cites W2007034352 @default.
- W4237632192 cites W2008915593 @default.
- W4237632192 cites W2023271753 @default.
- W4237632192 cites W2038404544 @default.
- W4237632192 cites W2053700413 @default.
- W4237632192 cites W2091238480 @default.
- W4237632192 cites W2092157292 @default.
- W4237632192 cites W2096747776 @default.
- W4237632192 cites W2101953984 @default.
- W4237632192 cites W2115394865 @default.
- W4237632192 cites W2143981217 @default.
- W4237632192 cites W2151090807 @default.
- W4237632192 cites W2152704902 @default.
- W4237632192 cites W2164820866 @default.
- W4237632192 cites W2613905013 @default.
- W4237632192 cites W2614348750 @default.
- W4237632192 cites W2616645753 @default.
- W4237632192 cites W2737184883 @default.
- W4237632192 cites W2782741781 @default.
- W4237632192 cites W2921838329 @default.
- W4237632192 cites W3025081413 @default.
- W4237632192 doi "https://doi.org/10.1002/ange.202008919" @default.
- W4237632192 hasPublicationYear "2020" @default.
- W4237632192 type Work @default.
- W4237632192 citedByCount "1" @default.
- W4237632192 countsByYear W42376321922021 @default.
- W4237632192 crossrefType "journal-article" @default.
- W4237632192 hasAuthorship W4237632192A5024722452 @default.
- W4237632192 hasAuthorship W4237632192A5030863006 @default.
- W4237632192 hasBestOaLocation W42376321921 @default.
- W4237632192 hasConcept C104317684 @default.
- W4237632192 hasConcept C121332964 @default.
- W4237632192 hasConcept C143065580 @default.
- W4237632192 hasConcept C161790260 @default.
- W4237632192 hasConcept C171999351 @default.
- W4237632192 hasConcept C181199279 @default.
- W4237632192 hasConcept C185592680 @default.
- W4237632192 hasConcept C2777120639 @default.
- W4237632192 hasConcept C2780595602 @default.
- W4237632192 hasConcept C55493867 @default.
- W4237632192 hasConcept C62520636 @default.
- W4237632192 hasConcept C65024703 @default.
- W4237632192 hasConcept C71240020 @default.
- W4237632192 hasConcept C75079739 @default.
- W4237632192 hasConcept C89611455 @default.
- W4237632192 hasConceptScore W4237632192C104317684 @default.
- W4237632192 hasConceptScore W4237632192C121332964 @default.
- W4237632192 hasConceptScore W4237632192C143065580 @default.
- W4237632192 hasConceptScore W4237632192C161790260 @default.
- W4237632192 hasConceptScore W4237632192C171999351 @default.
- W4237632192 hasConceptScore W4237632192C181199279 @default.
- W4237632192 hasConceptScore W4237632192C185592680 @default.
- W4237632192 hasConceptScore W4237632192C2777120639 @default.
- W4237632192 hasConceptScore W4237632192C2780595602 @default.
- W4237632192 hasConceptScore W4237632192C55493867 @default.
- W4237632192 hasConceptScore W4237632192C62520636 @default.
- W4237632192 hasConceptScore W4237632192C65024703 @default.
- W4237632192 hasConceptScore W4237632192C71240020 @default.
- W4237632192 hasConceptScore W4237632192C75079739 @default.
- W4237632192 hasConceptScore W4237632192C89611455 @default.
- W4237632192 hasFunder F4320322581 @default.
- W4237632192 hasIssue "51" @default.
- W4237632192 hasLocation W42376321921 @default.
- W4237632192 hasOpenAccess W4237632192 @default.
- W4237632192 hasPrimaryLocation W42376321921 @default.
- W4237632192 hasRelatedWork W1832892986 @default.
- W4237632192 hasRelatedWork W1997206792 @default.
- W4237632192 hasRelatedWork W2060566628 @default.
- W4237632192 hasRelatedWork W2355151844 @default.
- W4237632192 hasRelatedWork W2405385153 @default.
- W4237632192 hasRelatedWork W2406910599 @default.
- W4237632192 hasRelatedWork W2950538501 @default.
- W4237632192 hasRelatedWork W2951533543 @default.
- W4237632192 hasRelatedWork W3085866346 @default.
- W4237632192 hasRelatedWork W4237632192 @default.
- W4237632192 hasVolume "132" @default.
- W4237632192 isParatext "false" @default.
- W4237632192 isRetracted "false" @default.
- W4237632192 workType "article" @default.