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• W4237682786 endingPage "1402" @default.
• W4237682786 startingPage "1389" @default.
• W4237682786 abstract "A single 880-base-pair region within the genome of simian cytomegalovirus strain Colburn contains sequences that hybridize intensely with both human and mouse total genome DNA probes. This sequence was also found in a second simian cytomegalovirus isolate and was retained in both plaque-purified virus subclones and in plasmid DNA clones containing the SalI P fragment. Cleaved genomic DNAs from several mammalian species all exhibited strong dispersed hybridization with the SalI-P probes, and over 70% of the lambda clones in a mouse genomic library plus several selected clones containing globin, 45S rDNA, or 5S rDNA genes all formed hybrids with SalI-P. The appropriate region of cytomegalovirus SalI-P contains relatively A + T-rich unique sequences interrupted by three stretches of the simple alternating dinucleotides, (CA)15, (CA)22, and (CA)21, which we show to be responsible for most of the cell-virus homology. We conclude that discrete, tandemly repeated (CA) dinucleotide tracts capable of forming left-handed Z-DNA helices punctuate mammalian genomes at greater than 10(5) copies per cell and that three adjacent copies of what appear to be a family of interspersed repetitive elements containing these (CA)n stretches are carried in the genomes of simian cytomegaloviruses." @default.
• W4237682786 created "2022-05-12" @default.
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• W4237682786 date "1983-08-01" @default.
• W4237682786 modified "2023-10-17" @default.
• W4237682786 title "A Cytomegalovirus DNA Sequence Containing Tracts of Tandemly Repeated CA Dinucleotides Hybridizes to Highly Repetitive Dispersed Elements in Mammalian Cell Genomes" @default.
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• W4237682786 doi "https://doi.org/10.1128/mcb.3.8.1389-1402.1983" @default.
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