Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237690614> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4237690614 endingPage "xii" @default.
- W4237690614 startingPage "i" @default.
- W4237690614 abstract "Leucocytes play an essential role in the pathogenesis of ischaemia and reperfusion injury and inhibition of their adhesion and of mediator release can reduce vascular and tissue damage. Previous studies have shown that cloricromene modifies several granulocyte as well as monocyte/macrophage functions and it has been shown that cloricromene administration exerts a clear protective action in several experimental models of ischaemia. The present work describes new data on polymorphonuclear leukocyte (PMN) inhibition exerted by cloricromene and compares these observations with earlier ones. Human washed PMN and human whole blood (HWB) were studied in vitro upon stimulation with f-MLP in the presence of cytochalasin B, with opsonized zymosan and with a phorbol ester (PMA). Amongst free radicals, superoxide anions were chosen as index of oxidative burst. Phagocytosis and β-glucuronidase, as lysosomal release indicators, were measured to characterize PMN function: cloricromene inhibited concentration-dependently all the parameters upon stimulation by each activator tested. Experiments performed in rabbit whole blood (RWB) showed that cloricromene inhibited free radical generation with IC50values similar to those obtained in human whole blood. Comparing the action of cloricromene on human cells in different tests, we found that some parameters were more sensitive than others, even when the same stimulus was used. In particular, free radical generation was inhibited by cloricromene with IC50values below 36 μm, while other functions, like lysosomal release and phagocytosis were inhibited with IC50values over 100 μm. These data confirm that cloricromene exerts a notable inhibitory effect on PMN and may explain the activity of the compound, observed in vivo in several experimental models of ischaemia–reperfusion and shock.pc 1999 Academic [email protected]$hr" @default.
- W4237690614 created "2022-05-12" @default.
- W4237690614 date "1999-12-01" @default.
- W4237690614 modified "2023-10-14" @default.
- W4237690614 title "Volume contents and index" @default.
- W4237690614 doi "https://doi.org/10.1006/phrs.1999.0624" @default.
- W4237690614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10712825" @default.
- W4237690614 hasPublicationYear "1999" @default.
- W4237690614 type Work @default.
- W4237690614 citedByCount "0" @default.
- W4237690614 crossrefType "journal-article" @default.
- W4237690614 hasConcept C134018914 @default.
- W4237690614 hasConcept C160448771 @default.
- W4237690614 hasConcept C1621761 @default.
- W4237690614 hasConcept C181199279 @default.
- W4237690614 hasConcept C185592680 @default.
- W4237690614 hasConcept C202751555 @default.
- W4237690614 hasConcept C203014093 @default.
- W4237690614 hasConcept C24998067 @default.
- W4237690614 hasConcept C2777983669 @default.
- W4237690614 hasConcept C2778870864 @default.
- W4237690614 hasConcept C2779012151 @default.
- W4237690614 hasConcept C2780795997 @default.
- W4237690614 hasConcept C55493867 @default.
- W4237690614 hasConcept C86803240 @default.
- W4237690614 hasConcept C89372155 @default.
- W4237690614 hasConcept C98274493 @default.
- W4237690614 hasConcept C99971728 @default.
- W4237690614 hasConceptScore W4237690614C134018914 @default.
- W4237690614 hasConceptScore W4237690614C160448771 @default.
- W4237690614 hasConceptScore W4237690614C1621761 @default.
- W4237690614 hasConceptScore W4237690614C181199279 @default.
- W4237690614 hasConceptScore W4237690614C185592680 @default.
- W4237690614 hasConceptScore W4237690614C202751555 @default.
- W4237690614 hasConceptScore W4237690614C203014093 @default.
- W4237690614 hasConceptScore W4237690614C24998067 @default.
- W4237690614 hasConceptScore W4237690614C2777983669 @default.
- W4237690614 hasConceptScore W4237690614C2778870864 @default.
- W4237690614 hasConceptScore W4237690614C2779012151 @default.
- W4237690614 hasConceptScore W4237690614C2780795997 @default.
- W4237690614 hasConceptScore W4237690614C55493867 @default.
- W4237690614 hasConceptScore W4237690614C86803240 @default.
- W4237690614 hasConceptScore W4237690614C89372155 @default.
- W4237690614 hasConceptScore W4237690614C98274493 @default.
- W4237690614 hasConceptScore W4237690614C99971728 @default.
- W4237690614 hasIssue "6" @default.
- W4237690614 hasLocation W42376906141 @default.
- W4237690614 hasLocation W42376906142 @default.
- W4237690614 hasOpenAccess W4237690614 @default.
- W4237690614 hasPrimaryLocation W42376906141 @default.
- W4237690614 hasRelatedWork W1930695910 @default.
- W4237690614 hasRelatedWork W2014103626 @default.
- W4237690614 hasRelatedWork W2095124806 @default.
- W4237690614 hasRelatedWork W2097452661 @default.
- W4237690614 hasRelatedWork W2100243504 @default.
- W4237690614 hasRelatedWork W2121396423 @default.
- W4237690614 hasRelatedWork W2148068424 @default.
- W4237690614 hasRelatedWork W2306238042 @default.
- W4237690614 hasRelatedWork W2327838432 @default.
- W4237690614 hasRelatedWork W2331245361 @default.
- W4237690614 hasVolume "40" @default.
- W4237690614 isParatext "false" @default.
- W4237690614 isRetracted "false" @default.
- W4237690614 workType "article" @default.