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- W4237709823 abstract "There are two well-known subpopulations of activated platelets: pro-aggregatory and procoagulant. Procoagulant platelets represent a subpopulation of activated platelets, which are morphologically and functionally distinct from pro-aggregatory ones. Although various names have been used to describe these platelets in the literature (CoaT, CoaTed, highly activated, ballooned, capped, etc.), there is a consensus on their phenotypic features including exposure of high levels of phosphatidylserine (PSer) on the surface; decreased aggregatory and adhesive properties; support of active tenase and prothrombinase complexes; maximal generation by co-stimulation of glycoprotein VI (GPVI) and protease-activated receptors (PAR). In this chapter, morphologic and functional features of procoagulant platelets, as well as the mechanisms of their formation, will be discussed." @default.
- W4237709823 created "2022-05-12" @default.
- W4237709823 creator A5047135257 @default.
- W4237709823 date "2020-11-11" @default.
- W4237709823 modified "2023-10-17" @default.
- W4237709823 title "Procoagulant Platelets" @default.
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- W4237709823 doi "https://doi.org/10.5772/intechopen.92638" @default.
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