Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237746275> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W4237746275 abstract "Filarial nematodes, including Dirofilaria immitis and D. repens, harbour intracellular bacteria belonging to the genus Wolbachia. These bacteria have been implicated in the pathogenesis of filarial diseases, possibly through their endotoxins. Recent studies have shown that a major surface protein of Wolbachia (WSP) induces a specific IgG response in hosts infected by D. immitis. WSP from the Wolbachia of D. immitis was produced in recombinant form. The purified protein was used in stimulation assays on canine neutrophils. The assays performed using a modified Boyden chamber showed that WSP stimulates neutrophil chemokinesis. In addition, RT-PCR revealed increased production of chemokine IL-8 by cells incubated with this protein. Neutrophils have been shown to play a major role in the pathogenesis of river blindness, and to accumulate in the nodules of onchocerciasis patients. In dogs infected by D. immitis, neutrophils accumulate in kidneys and in the wall of pulmonary arteries. As shown by our studies, Wolbachia could contribute to these inflammatory phenomena through its surface protein WSP, independently from its endotoxin component." @default.
- W4237746275 created "2022-05-12" @default.
- W4237746275 creator A5020695339 @default.
- W4237746275 date "2003-09-24" @default.
- W4237746275 modified "2023-09-27" @default.
- W4237746275 title "Immunological role of the endosymbionts of Dirofilaria immitis: the Wolbachia surface protein activates canine neutrophils with production of IL-8" @default.
- W4237746275 doi "https://doi.org/10.1016/s0304-4017(03)00303-0" @default.
- W4237746275 hasPublicationYear "2003" @default.
- W4237746275 type Work @default.
- W4237746275 citedByCount "0" @default.
- W4237746275 crossrefType "journal-article" @default.
- W4237746275 hasAuthorship W4237746275A5020695339 @default.
- W4237746275 hasConcept C159047783 @default.
- W4237746275 hasConcept C165901193 @default.
- W4237746275 hasConcept C203014093 @default.
- W4237746275 hasConcept C2776355835 @default.
- W4237746275 hasConcept C2777629521 @default.
- W4237746275 hasConcept C2778943559 @default.
- W4237746275 hasConcept C2779356413 @default.
- W4237746275 hasConcept C2780376107 @default.
- W4237746275 hasConcept C2780942790 @default.
- W4237746275 hasConcept C523546767 @default.
- W4237746275 hasConcept C54355233 @default.
- W4237746275 hasConcept C86803240 @default.
- W4237746275 hasConcept C89423630 @default.
- W4237746275 hasConceptScore W4237746275C159047783 @default.
- W4237746275 hasConceptScore W4237746275C165901193 @default.
- W4237746275 hasConceptScore W4237746275C203014093 @default.
- W4237746275 hasConceptScore W4237746275C2776355835 @default.
- W4237746275 hasConceptScore W4237746275C2777629521 @default.
- W4237746275 hasConceptScore W4237746275C2778943559 @default.
- W4237746275 hasConceptScore W4237746275C2779356413 @default.
- W4237746275 hasConceptScore W4237746275C2780376107 @default.
- W4237746275 hasConceptScore W4237746275C2780942790 @default.
- W4237746275 hasConceptScore W4237746275C523546767 @default.
- W4237746275 hasConceptScore W4237746275C54355233 @default.
- W4237746275 hasConceptScore W4237746275C86803240 @default.
- W4237746275 hasConceptScore W4237746275C89423630 @default.
- W4237746275 hasLocation W42377462751 @default.
- W4237746275 hasOpenAccess W4237746275 @default.
- W4237746275 hasPrimaryLocation W42377462751 @default.
- W4237746275 hasRelatedWork W2008217226 @default.
- W4237746275 hasRelatedWork W2011785098 @default.
- W4237746275 hasRelatedWork W2013884308 @default.
- W4237746275 hasRelatedWork W2168985345 @default.
- W4237746275 hasRelatedWork W2249026823 @default.
- W4237746275 hasRelatedWork W292291835 @default.
- W4237746275 hasRelatedWork W2964961586 @default.
- W4237746275 hasRelatedWork W3026032888 @default.
- W4237746275 hasRelatedWork W3035815136 @default.
- W4237746275 hasRelatedWork W3176973440 @default.
- W4237746275 isParatext "false" @default.
- W4237746275 isRetracted "false" @default.
- W4237746275 workType "article" @default.