Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237764028> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4237764028 endingPage "927" @default.
- W4237764028 startingPage "917" @default.
- W4237764028 abstract "This study examined the effect of erythropoietin (EPO) on resting tension and on the responses of rat mesenteric and renal arcuate arteries in vitro to a number of agonists as a possible cause of its blood pressure elevating properties when used therapeutically. Noradrenaline and potassium chloride induced concentration-dependent vasoconstrictions in both vessel types but the basal tension, maximum tension, and the -log concentration producing half-maximal response (pEC50) were altered in the presence of 0·1 or 20 U ml−1 EPO. The thromboxane A2 receptor agonist U46619 induced a constriction of the renal arcuate arteries which was enhanced by EPO at 20 U ml−1, from 1·68 ± 0·34 to 2·64 ± 0·39 mN mm−1 (P < 0·01), but which was unchanged by NG-nitro-L-arginine methyl ester (10−4 m). Serotonin (10−9-10−5 M) caused a concentration-related vasoconstriction in renal arcuate arteries which was shifted to the right in the time control study (P < 0·001) but this was abolished by both 0·1 and 20 U ml−1 of EPO. Acetylcholine induced a relaxation of precontracted mesenteric arteries, by 95·4 ± 1·64% with an EC50 of 7·08 ± 0·08 M which was reduced (P < 0·001) by 20 U ml−1 EPO to 81·7 ± 3·56% and 6·10 ± 0·11 M, respectively. The sodium nitroprusside-induced relaxations were unaffected by EPO. The acetylcholine-mediated relaxations in renal arcuate arteries were unchanged by EPO. Bradykinin-induced relaxations in mesenteric and renal arcuate arteries were unaffected by both EPO concentrations. Together these data showed that EPO over a large concentration range had only minor effects on basal tension and the vascular responsiveness of both mesenteric and renal arcuate arteries. The mechanism whereby EPO causes a chronic elevation in blood pressure is unlikely to be due to acute interactions with agonist-mediated responses." @default.
- W4237764028 created "2022-05-12" @default.
- W4237764028 creator A5008691009 @default.
- W4237764028 creator A5010778183 @default.
- W4237764028 creator A5063604353 @default.
- W4237764028 date "1999-09-01" @default.
- W4237764028 modified "2023-10-14" @default.
- W4237764028 title "THE INFLUENCE OF ERYTHROPOIETIN ON THE VASCULAR RESPONSES OF RAT RESISTANCE ARTERIES" @default.
- W4237764028 doi "https://doi.org/10.1017/s0958067099019107" @default.
- W4237764028 hasPublicationYear "1999" @default.
- W4237764028 type Work @default.
- W4237764028 citedByCount "2" @default.
- W4237764028 crossrefType "journal-article" @default.
- W4237764028 hasAuthorship W4237764028A5008691009 @default.
- W4237764028 hasAuthorship W4237764028A5010778183 @default.
- W4237764028 hasAuthorship W4237764028A5063604353 @default.
- W4237764028 hasBestOaLocation W42377640281 @default.
- W4237764028 hasConcept C120770815 @default.
- W4237764028 hasConcept C126322002 @default.
- W4237764028 hasConcept C134018914 @default.
- W4237764028 hasConcept C170493617 @default.
- W4237764028 hasConcept C185592680 @default.
- W4237764028 hasConcept C2776820930 @default.
- W4237764028 hasConcept C2777663904 @default.
- W4237764028 hasConcept C2778534260 @default.
- W4237764028 hasConcept C2778938600 @default.
- W4237764028 hasConcept C2779591629 @default.
- W4237764028 hasConcept C2779610285 @default.
- W4237764028 hasConcept C2779961880 @default.
- W4237764028 hasConcept C2780771799 @default.
- W4237764028 hasConcept C519581460 @default.
- W4237764028 hasConcept C71924100 @default.
- W4237764028 hasConceptScore W4237764028C120770815 @default.
- W4237764028 hasConceptScore W4237764028C126322002 @default.
- W4237764028 hasConceptScore W4237764028C134018914 @default.
- W4237764028 hasConceptScore W4237764028C170493617 @default.
- W4237764028 hasConceptScore W4237764028C185592680 @default.
- W4237764028 hasConceptScore W4237764028C2776820930 @default.
- W4237764028 hasConceptScore W4237764028C2777663904 @default.
- W4237764028 hasConceptScore W4237764028C2778534260 @default.
- W4237764028 hasConceptScore W4237764028C2778938600 @default.
- W4237764028 hasConceptScore W4237764028C2779591629 @default.
- W4237764028 hasConceptScore W4237764028C2779610285 @default.
- W4237764028 hasConceptScore W4237764028C2779961880 @default.
- W4237764028 hasConceptScore W4237764028C2780771799 @default.
- W4237764028 hasConceptScore W4237764028C519581460 @default.
- W4237764028 hasConceptScore W4237764028C71924100 @default.
- W4237764028 hasIssue "5" @default.
- W4237764028 hasLocation W42377640281 @default.
- W4237764028 hasOpenAccess W4237764028 @default.
- W4237764028 hasPrimaryLocation W42377640281 @default.
- W4237764028 hasRelatedWork W1938580125 @default.
- W4237764028 hasRelatedWork W1990927425 @default.
- W4237764028 hasRelatedWork W2001390795 @default.
- W4237764028 hasRelatedWork W2044091624 @default.
- W4237764028 hasRelatedWork W2064376467 @default.
- W4237764028 hasRelatedWork W2140981622 @default.
- W4237764028 hasRelatedWork W2163473590 @default.
- W4237764028 hasRelatedWork W2205557529 @default.
- W4237764028 hasRelatedWork W2754881533 @default.
- W4237764028 hasRelatedWork W2810230849 @default.
- W4237764028 hasVolume "84" @default.
- W4237764028 isParatext "false" @default.
- W4237764028 isRetracted "false" @default.
- W4237764028 workType "article" @default.