FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4237781666> ?p ?o ?g. }

• W4237781666 endingPage "8375" @default.
• W4237781666 startingPage "8365" @default.
• W4237781666 abstract "Transcriptional activator proteins stimulate the formation of a preinitiation complex that may be distinct from a basal-level transcription complex in its composition and stability. Components of the general transcription factors that form activator-dependent stable intermediates were determined by the use of Sarkosyl and oligonucleotide challenge experiments. High-level transcriptional activation by the Epstein-Barr virus-encoded Zta protein required an activity in the TFIID fraction that is distinct from the TATA-binding protein (TBP) and the TBP-associated factors. This additional activity copurifies with and is likely to be identical to the previously defined coactivator, USA (M. Meisterernst, A. L. Roy, H. M. Lieu, and R. G. Roeder, Cell 66:981-994, 1991). The formation of a stable preinitiation complex intermediate resistant to Sarkosyl required the preincubation of the promoter DNA with Zta, holo-TFIID (TBP and TBP-associated factors), TFIIB, TFIIA, and the coactivator USA. The formation of a Zta response element-resistant preinitiation complex required the preincubation of promoter DNA with Zta, holo-TFIID, TFIIB, and TFIIA. Agarose gel electrophoretic mobility shift showed that a preformed Zta-holo-TFIID-TFIIA complex was resistant to Sarkosyl and to Zta response element oligonucleotide challenge. DNase I footprinting suggests that only Zta, holo-TFIID, and TFIIA make significant contacts with the promoter DNA. These results provide functional and physical evidence that the Zta transcriptional activator influences at least two distinct steps in preinitiation complex assembly, the formation of the stable holo-TFIID-TFIIA-promoter complex and the subsequent binding of TFIIB and a USA-like coactivator." @default.
• W4237781666 created "2022-05-12" @default.
• W4237781666 creator A5064696395 @default.
• W4237781666 date "1994-12-01" @default.
• W4237781666 modified "2023-09-30" @default.
• W4237781666 title "Identification of functional targets of the Zta transcriptional activator by formation of stable preinitiation complex intermediates" @default.
• W4237781666 cites W102825632 @default.
• W4237781666 cites W1558941855 @default.
• W4237781666 cites W1583104418 @default.
• W4237781666 cites W1584200049 @default.
• W4237781666 cites W1589670515 @default.
• W4237781666 cites W1596401901 @default.
• W4237781666 cites W1605064581 @default.
• W4237781666 cites W1759777836 @default.
• W4237781666 cites W1924232164 @default.
• W4237781666 cites W1967447574 @default.
• W4237781666 cites W1976580631 @default.
• W4237781666 cites W1977347668 @default.
• W4237781666 cites W1985235553 @default.
• W4237781666 cites W1986473194 @default.
• W4237781666 cites W1993243592 @default.
• W4237781666 cites W1993644340 @default.
• W4237781666 cites W1994252934 @default.
• W4237781666 cites W1996251138 @default.
• W4237781666 cites W2004796688 @default.
• W4237781666 cites W2006630070 @default.
• W4237781666 cites W2010026543 @default.
• W4237781666 cites W2013980278 @default.
• W4237781666 cites W2021893003 @default.
• W4237781666 cites W2027216583 @default.
• W4237781666 cites W2027570258 @default.
• W4237781666 cites W2032694235 @default.
• W4237781666 cites W2042157210 @default.
• W4237781666 cites W2042383781 @default.
• W4237781666 cites W2042425655 @default.
• W4237781666 cites W2050766639 @default.
• W4237781666 cites W2051520501 @default.
• W4237781666 cites W2054435912 @default.
• W4237781666 cites W2062181306 @default.
• W4237781666 cites W2065679706 @default.
• W4237781666 cites W2074624482 @default.
• W4237781666 cites W2074701310 @default.
• W4237781666 cites W2075263567 @default.
• W4237781666 cites W2079557259 @default.
• W4237781666 cites W2084229225 @default.
• W4237781666 cites W2086470847 @default.
• W4237781666 cites W2091423718 @default.
• W4237781666 cites W2107624922 @default.
• W4237781666 cites W2120434953 @default.
• W4237781666 cites W2128537226 @default.
• W4237781666 cites W2136690570 @default.
• W4237781666 cites W2140134113 @default.
• W4237781666 cites W2142731245 @default.
• W4237781666 cites W2155719842 @default.
• W4237781666 cites W2164313428 @default.
• W4237781666 cites W4246505086 @default.
• W4237781666 doi "https://doi.org/10.1128/mcb.14.12.8365-8375.1994" @default.
• W4237781666 hasPublicationYear "1994" @default.
• W4237781666 type Work @default.
• W4237781666 citedByCount "1" @default.
• W4237781666 crossrefType "journal-article" @default.
• W4237781666 hasAuthorship W4237781666A5064696395 @default.
• W4237781666 hasConcept C101762097 @default.
• W4237781666 hasConcept C102622118 @default.
• W4237781666 hasConcept C104317684 @default.
• W4237781666 hasConcept C105208137 @default.
• W4237781666 hasConcept C138885662 @default.
• W4237781666 hasConcept C144825837 @default.
• W4237781666 hasConcept C150194340 @default.
• W4237781666 hasConcept C153911025 @default.
• W4237781666 hasConcept C154816499 @default.
• W4237781666 hasConcept C179926584 @default.
• W4237781666 hasConcept C188740287 @default.
• W4237781666 hasConcept C27153228 @default.
• W4237781666 hasConcept C41895202 @default.
• W4237781666 hasConcept C44498088 @default.
• W4237781666 hasConcept C54355233 @default.
• W4237781666 hasConcept C65888428 @default.
• W4237781666 hasConcept C77445288 @default.
• W4237781666 hasConcept C86339819 @default.
• W4237781666 hasConcept C86803240 @default.
• W4237781666 hasConcept C95444343 @default.
• W4237781666 hasConceptScore W4237781666C101762097 @default.
• W4237781666 hasConceptScore W4237781666C102622118 @default.
• W4237781666 hasConceptScore W4237781666C104317684 @default.
• W4237781666 hasConceptScore W4237781666C105208137 @default.
• W4237781666 hasConceptScore W4237781666C138885662 @default.
• W4237781666 hasConceptScore W4237781666C144825837 @default.
• W4237781666 hasConceptScore W4237781666C150194340 @default.
• W4237781666 hasConceptScore W4237781666C153911025 @default.
• W4237781666 hasConceptScore W4237781666C154816499 @default.
• W4237781666 hasConceptScore W4237781666C179926584 @default.
• W4237781666 hasConceptScore W4237781666C188740287 @default.
• W4237781666 hasConceptScore W4237781666C27153228 @default.
• W4237781666 hasConceptScore W4237781666C41895202 @default.
• W4237781666 hasConceptScore W4237781666C44498088 @default.
• W4237781666 hasConceptScore W4237781666C54355233 @default.
• W4237781666 hasConceptScore W4237781666C65888428 @default.

• next